The varicella zoster virus primarily causes chickenpox. Herpes zoster is a typical late manifestation with reactivation of latent virus in sensory ganglia. Chickenpox is a highly contagious disease. Herpes zoster has been assumed to be less contagious, but studies have shown that reactivation of the varicella zoster virus also leads to significant spread of the virus (1–4). There has been incre...

BACKGROUND After allogeneic hematopoietic stem-cell transplantation patients are at increased risk for herpes zoster as long as varicella-zoster virus specific T-cell reconstitution is impaired. This study aimed to identify immunodominant varicella-zoster virus antigens that drive recovery of virus-specific T cells after transplantation. DESIGN AND METHODS Antigens were purified from a varice...

acyclovir (9-[2-hydroxyethoxymethyl] guanine) is an acyclic nucleoside analogue of guanosine which is a potent and selective antiviral agent. acycloviris converted to the monophosphate by thymidine kinase the virus-specific form of this enzyme and is subsequently converted to the triphosphate by the host cell kinase. acyclovir triphosphate inhibits viral dna-polymerase terminating the chain and...

Varicella zoster virus causes two distinct clinical diseases. Varicella is the primary infection and results from exposure of a person susceptible to the virus. The virus remains latent in cranial nerve ganglia, dorsal root ganglia, and autonomic ganglia along the entire neuraxis. Years later, in association with a decline in cell-mediated immunity in the elderly and immuno-compromised, varicel...

introduction : frosted branch angiitis(fba) is a panuveitis with sheating of all retinal vesssels. case presentation : herein we report an immunocompetent person who presented with fever, headache, atypical rash, and hazy vision. ophthalmoscopy of both eyes revealed perivascular sheathing with frosted branch angiitis pattern in veins, patchy retinal hemorrhages. aqueous pcr analysis turned posi...

results of all the ms patients, 78 (95.1%) and 21 (25.6%) were positive for anti-vzv and vzv dna, respectively. statistical analysis of the pcr results showed a significant correlation between the abundance of vzv and ms disease (p < 0.001). however, there was no significant correlation between the abundance of anti-vzv antibodies and ms disease by the elisa method. conclusions these results su...

The DNAs of a varicella-zoster virus vaccine and its parental virus were compared by CsCl buoyant density centrifugation and restriction enzyme cleavage analysis. The varicella-zoster virus vaccine DNA showed a heterogeneous buoyant profile and altered restriction enzyme cleavage patterns. These changed properties are probably the result of the accumulation of virus containing defective varicel...

The varicella zoster virus is the causative agent of herpes zoster and varicella. In herpes zoster, the virus dormant within dorsal root ganglia is reactivated, resulting in painful vesicular lesions overlying an erythematous base.

background and objective: varicella zoster virus (vzv) can cause life-threatening disease in pregnant women. the aim of this study was to identify the vzv immune status in pregnant women and also determine the validity of self-reported history for chickenpox. methods: serologic testing for vzv was performed for 400 pregnant women attending prenatal care at clinics located in two teaching and re...