Unnatural chiral α-amino acids are widely used in fields of organic chemistry, biochemistry and medicinal chemistry, and their synthesis has attracted extensive attention. Although the asymmetric synthesis provides some efficient protocols, noble and elaborate catalysts, ligands and additives are usually required which leads to high cost. Distinctly, it is attractive to make unnatural chiral α-...

A comparative theoretical study is presented on the formation and fate of α-amino-peroxyl radicals, recently proposed as important intermediates in the aerobic oxidation of amines. After radical abstraction of the weakly bonded αH-atom in the amine substrate, the α-amino-alkyl radical reacts irreversibly with O(2), forming the corresponding α-amino-peroxyl radical. HO(2)˙-elimination from vario...

The importance of nitriles as a key class chemicals with applications across the sciences is widely appreciated. natural world an underappreciated source chemically diverse nitriles. With this in mind, review describes novel nitrile-containing molecules isolated from sources 1998 to 2021, well discussion biological activity these compounds. This study gathers 192 varied origins plant, animal, a...

We systematically investigated the reversibility, time lapse, and oxygenation-deoxygenation properties of 15 natural α-amino acid-Co(II) complexes through UV-vis spectrophotometer, polarographic oxygen electrode, and DFT calculations, respectively, to explore the relationship between the coordinating structure and reversible oxygenation of α-amino acid-Co(II) complexes. Results revealed that th...

The first example of copper-catalyzed ring-opening, enantioselective arylation cyclic ketoxime esters to access ω,ω-diaryl alkyl nitriles has been developed in high yield (up 92% yield) with excellent enantioselectivity 91% ee). Side-arm bis(oxazoline) ligand plays a significant role this asymmetric catalytic transformation, which provides an efficient route construct diverse chiral nitriles. S...

Ruthenium, rhodium, iridium, and rhenium hydride complexes are highly useful redox Lewis acid and base catalysts. Various substrates bearing hetero atoms are activated by these catalysts and undergo reactions with either nucleophiles or electrophiles under neutral conditions. These types of catalytic reactions are described together with their application to the preparation of various biologica...

2-Amino-4-benzoyl-1-arylpyrrole-3-carbonitriles react with arylidene malonodinitriles, β-ketoesters and βdiketones to afford pyrrolo[2,3-b]pyridine derivatives.