An 80-year-old woman, who had been administered α-glucosidase inhibitor for diabetes, was brought to the hospital with the sensation of abdominal fullness and pain. Abdominal computed tomography indicated pneumatosis cystoides intestinalis (PCI) in the small intestinal wall, with free air within the abdomen. A blood examination showed no increases in white blood cells or C-reactive protein leve...

Objective: The purpose of this study is to isolate and characterize the andrographolide betulin from methanolic leaves extract Andrographis echioides also used evaluate alpha-amylase alpha-glucosidase inhibitory activity isolated compounds using in silico docking studies.
 Methods: isolation was done column chromatography gradient mobile phase. Structural elucidation carried out on basis s...

Abstract Background Tetracarpidium conophorum is one of the numerous folklore medicinal plants for managing diabetes but mode action and bioactive compounds responsible antihyperglycemic property are missing in literatures. This study aimed at investigating possible modes its using both in-vitro ex-vivo methods. Powdered seed (TECOSE) was extracted with methanol standard extraction procedure. G...

A wide range of proteinaceous inhibitors are present in plants to protect themselves from hydrolytic enzymes. In this study, turmerin, a water-soluble peptide in turmeric rhizomes, was evaluated for its inhibitory potential against glucosidase and its antioxidant (AO) capacity. Turmerin inhibited α-amylase and α-glucosidase activities with IC₅₀ values 31 and 192 µg mL⁻¹, respectively. Under the...

Background:α-Glucosidase Inhibition can significantly prevent glucose uptake after meal, and helps in controlling of some adverse effects in diabetics. So determination of α-Glucosidase inhibitory effect and antioxidant activity of the Haplophyllum acutifolium and Ferula haussknechtii aerial organs was the aim of this study.Methods:Inhibitory effect of hexane extracts from dif...

Background:α-Glucosidase Inhibition can significantly prevent glucose uptake after meal, and helps in controlling of some adverse effects in diabetics. So determination of α-Glucosidase inhibitory effect and antioxidant activity of the Haplophyllum acutifolium and Ferula haussknechtii aerial organs was the aim of this study.Methods:Inhibitory effect of hexane extracts from dif...

The studies on the effects of arabinoxylan (AX) polysaccharides on postprandial glucose response have resulted in contrasting results owing to the diversity in AX structures. Four water extractable AX (WEAX) extracts obtained from wheat aleurone and bran were used to investigate (a) the effect of AX on activities of α-amylase and α-glucosidase, (b) influence of AX chemical composition on their ...

Inhibitory effects of root endophytic actinomycete A-12 from Azadirachta indica A. Juss (Indian lilac, neem) against α-amylase and α-glucosidase were studied. The antioxidant capability was assessed through 2,2-diphenyl-picrylhydrazyl (DPPH), hydroxy radical scavenging and reducing power assays. In vitro antidiabetic activity of ethyl acetate extract revealed good inhibition exhibiting IC50 val...

A dimeric acylphenol and a potent α-glucosidase inhibitor, giganteone D (IC50 5.05μM), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC50 358.80μM) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver-Burk plo...