The title compound, C19H20O6, consists of a tetra-substituted benzene ring with one substituent being an α,β-unsaturated cinnamoyl group, which forms an extended conjugated system in the mol-ecule. In addition, two meth-oxy-meth-oxy and one hy-droxy group are bonded to the central benzene ring. The dihedral angle between eh rings is 10.22 (10)°. An intra-molecular hydrogen bond is observed betw...

The sp3 C–H acetoxylation at the β-position of α,α-disubstituted α-amino acids proceeds smoothly under palladium catalysis in presence PhI(OAc)2. This reaction provides a straightforward synthetic route to non-natural β-acetoxy-α-amino acids. α-aminocyclopropanecarboxylic acid takes place via ring-opening selectively afford an acyclic γ-acetoxy-α,β-unsaturated amino acid.

The reaction of organic molecules mediated by a metal center (template synthesis) can result in final connectivity that may differ from the one obtained absence metal. condensation carbonyl fragments with primary amines form C=N iminic bonds, so-called Schiff bases, which act as ligands for templating means lone pair on nitrogen atom. This review focuses template methods between compound (mainl...

The title Schiff base compound, C28H21Cl2N3O, was synthesized by the condensation of 1-(3,4-di-chloro-phen-yl)-3-methyl-4-(4-methyl-benzo-yl)-1H-pyrazol-5(4H)-one with 1-aminona-phthalene. The p-tolyl ring is normal to the pyrazole ring, with a dihedral angle of 88.02 (14)°, and inclined to the naphthalene ring system by 78.60 (12)°. The pyrazole ring is inclined to the naphthalene ring system ...

The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations. Thus, the asymmetric a-allylation of carbonyl compounds, a-fluorination of acyl derivatives, decarboxylative protonation of β-dicarbonyl compounds, cyclization reactions of alkynyl carbonyl compounds and β-func...

Compounds active at neurotensin receptors (NTS1 and NTS2) exert analgesic effects on different types of nociceptive modalities, including thermal, mechanical, and chemical stimuli. The NTS2 preferring peptide JMV-431 (2) and the NTS2 selective nonpeptide compound levocabastine (6) have been shown to be effective in relieving the pain associated with peripheral neuropathies. With the aim of iden...

New benzohydrazone compound, 4-amino-N'-[(1E)-1-(2-hydroxy-6-methyl-4-oxo-4H-pyran-3-yl)ethylidene] benzohydrazide (HL1) and its Cu(II), Ni(II), Zn(II) Mn(II) complexes were synthesized. The structures of HL1 elucidated by elemental analysis IR, UV-Vis, 1H 13C NMR spectroscopy mass spectrometry. infrared spectral data the revealed that coordinated with metal ions through azomethine nitrogen, en...

The title compound, C(18)H(33)N(3)O(5), was prepared from N-tert-butoxy-carbonyl-4-piperidone using a nine-step reaction, including condensation, methyl-ation, oximation, hydrolysis, esterification, ammonolysis, Hoffmann degradation, tert-butoxy-carbonyl protection and methyl-ation. The E configuration of the methyl-oxime geometry of the compound is confirmed.

A formal synthesis of the antiviral drug (-)-oseltamivir (Tamiflu) has been accomplished starting from m-anisic acid via a dissolving metal or electrochemical Birch reduction. The correct absolute stereochemistry is efficiently set through enzyme-catalyzed carbonyl reduction on resultant racemic α,β-unsaturated ketone. screen broad ketoreductase (KRED) library identified several that deliver de...