BACKGROUND The epidermal growth factor receptor (EGFR) signaling pathway plays a significant role in radiation resistance. There is evidence that EGFR nuclear translocation is associated with DNA double-strand breaks (DSB) repair. Nimotuzumab has shown the effect of radiosensitization in various cancer cells, but little is known about the relationship between nimotuzumab and EGFR nuclear transl...

We present the first of two articles on the small volume fraction limit of a nonlocal Cahn–Hilliard functional introduced to model microphase separation of diblock copolymers. Here we focus attention on the sharp-interface version of the functional and consider a limit in which the volume fraction tends to zero but the number of minority phases (called particles) remains O(1). Using the languag...

We study, by means of Γ-convergence, the asymptotic behaviour of a variational problem modeling a dislocation ensemble moving on a slip plane through a discrete array of obstacles. The variational problem is a two dimensional phase transition type energy given by a non local term and a non linear potential which penalizes non integer values. In this paper we consider a regime corresponding to a...

To determine background radiation levels that might influence experiments, we measured in situ gamma-ray emissions at ten locations in the Boulby Underground Laboratory. For gamma radiation in the energy range of 7-2,734 keV, the counts varied from 6.5 to 28 γ s-1. For measurements inside the Lab, the arithmetic mean was 24 γ s-1. The sedimentary rocks that surrounded the Lab, halite and mudsto...

If cosmic ray protons interact with gas at roughly the mean density of the interstellar medium in starburst galaxies, then pion decay in starbursts is likely to contribute significantly to the diffuse extra-galactic background in both γ-rays and high energy neutrinos. We describe the assumptions that lead to this conclusion and clarify the difference between our estimates and those of Stecker (...

The present studies investigated the cellular mechanisms for the detrimental effects of high dose whole body γ-irradiation on bone. In addition, radioadaptation and bone marrow transplantation were assessed as interventions to mitigate the skeletal complications of irradiation. Increased trabecular thickness and separation and reduced cancellous bone volume fraction, connectivity density, and t...

We present an overview of the current theoretical models attempting to describe the structure and radiative processes operating in blazars and discuss the observational constraints that these models must confront. Many of these objects are found by CGRO to be strong high energy γ–ray sources. Their spectra consist of two broad components: the low-energy component, peaking between the infrared a...

Nano-size maghemite (γ-Fe2O3) particles were prepared in one step using ultrasound radiation. The obtained nanoparticles were characterized by SEM, TEM , XRD, FTIR, and VSM. The results revealed that the synthesized nanoparticles were spherical, mono-dispersed and uniform. Furthermore, the crystalline structure of nanoparticles endorsed by X-ray diffraction study. The FTIR spectra have provided...

PURPOSE To examine the influence of α-particle radiation exposure from internally deposited plutonium on chromosome aberration frequencies in peripheral blood lymphocytes of workers from the Sellafield nuclear facility, UK. MATERIALS AND METHODS Chromosome aberration data from historical single colour fluorescence in situ hybridization (sFISH) and Giemsa banding (G-banding) analyses, together...

Ionizing radiation induces biological effects not only in irradiated cells but also in non-irradiated cells, which is called the bystander effect. Recently, in vivo and in vitro experiments have suggested that both gap junction hemichannel connexin43 (Cx43) and extracellular adenosine triphosphate (ATP) released from cells play a role in the bystander effect. We have reported that γ-irradiation...