نتایج جستجو برای: ε4 allele
تعداد نتایج: 147786 فیلتر نتایج به سال:
Abstract Background Leukocyte telomere length (LTL) has been shown to predict Alzheimer’s disease (AD), albeit inconsistently. Failing account for the competing risks between AD, other dementia types, and mortality, can be an explanation inconsistent findings in previous time-to-event analyses. Furthermore, studies indicate that association LTL AD is non-linear may differ depending on apolipopr...
OBJECTIVES To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes. DESIGN Association study of AD and CLU, PICALM, CR1, and APOE genotypes. SETTING Academic research institutions in the United States, Canada, and Israel. PARTICIPANTS Seven thousand ...
Background Reduced amyloid-beta-42 (Aβ42) and elevated total tau (t-tau) protein concentrations in the CSF are characteristic of Alzheimer’s disease (AD) pathology [1]. Aβ42 contributes to extracellular plaque formation between neurons [2]. The level tau, a microtubule-stabilizer neuron axons [3], is associated with neuronal death Additionally, presence ApoE4 (ε4) alleles an established identif...
Tau abnormal hyperphosphorylation and the formation of neurofibrillary tangles in the Alzheimer's disease (AD) brain is the result of upregulation of tau kinases. In a group of 729 Spanish late-onset AD patients and 670 healthy controls, we examined variations into a set of 20 candidate genes of kinases involved in tau phosphorylation at AD-related sites (PRKACB; CAMK2A; MARK1, 2, 3 and 4; CSNK...
Background A growing body of evidence suggests a deteriorating effect sub-threshold amyloid-beta (Aβ) accumulation on cognition before the onset clinical symptoms Alzheimer’s disease. Despite association between Aβ-dependent pathway and APOE ε4 allele, impact this allele progression from Aβ deposits to cognitive function impairment is unclear. Furthermore, comparative analysis positive in precl...
The most recent studies about mild cognitive impairment (MCI) are focused on the search for factors that make patients more vulnerable to conversion to dementia, mainly Alzheimer's disease (AD). The aim of this study was to determine which neuropsychological test performances, including episodic memory profiles, and genetic risk factors (APOE ε4) better predict early conversion to dementia amon...
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