Forty-four Finnish volunteers who were previously studied with regard to the repair rate of UV-specific cyclobutane pyrimidine dimers in the skin were genotyped for XPD polymorphisms at codons 312 (exon 10 G-->A, Asp-->Asn) and 751 (exon 23 A-->C, Lys-->Gln). The repair rate was measured at 24 h for two different cyclobutane dimers. The data did not show consistent XPD genotype-specific differe...

Trichothiodystrophy (TTD) is a rare autosomal recessive disorder characterized by brittle hair and also associated with various systemic symptoms. Approximately half of TTD patients exhibit photosensitivity, resulting from the defect in the nucleotide excision repair. Photosensitive TTD is due to mutations in three genes encoding XPB, XPD and p8/TTDA subunits of the DNA repair/transcription fac...

The complex molecular motions central to the functions of helicases have long attracted attention. Protein crystallography has provided transformative insights into these dynamic conformational changes, however important questions about the true nature of helicase configurations during the catalytic cycle remain. Using pulsed EPR (PELDOR or DEER) to measure interdomain distances in solution, we...

Li- and Mn-rich layered oxides (LMR-NCMs) are promising cathode active materials (CAMs) in future lithium-ion batteries (LIBs) due to their high energy density. However, the material undergoes a unique open circuit voltage (OCV) hysteresis between charge discharge after activation, which compromises its roundtrip efficiency affects thermal management requirements for LIB system. The is believed...

This letter presents a wideband high performance 45° linearly polarization 8 × 8-slot array antenna. The gap waveguide technology is utilized to realize the proposed antenna, so that electromagnetic (EM) leakage among metallic blocks can be cancelled. 2 4-slot subarrays are used construct An additional cavity power divider layer inserted between layers of original dividers and radiation slots b...

Nucleotide Excision Repair (NER) is a pathway that removes lesions distorting the DNA helix. The molecular basis of the rare diseases Xeroderma pigmentosum (XP) and Cockayne Syndrome (CS) are explained based on the defects happening in 2 NER branches: Global-Genome Repair and Transcription-Coupled Repair, respectively. Nevertheless, both afflictions sporadically occur together, giving rise to X...

The reduction in the average required transmit power in order to achieve the desired system performance is determined when using a receive antenna array employing polarization diversity as opposed to spatial diversity only. Cross-polardiscrimination (XPD) and envelope correlation are used to model the correlation between the horizontal and vertical polarizations. The characteristic function for...