BACKGROUND The population-based impact of infection with swine origin influenza A (H1N1) virus infection was not clear in the early days of the epidemic towards the end of May 2009. Australia had seven confirmed cases by 22 May 2009. We aimed to compare available data on swine origin influenza A (H1N1) virus infection overseas with seasonal influenza A (H1N1) virus infection in Australia to ass...

The pandemic H1N1 virus of 2009 (2009 H1N1) continues to cause illness worldwide, primarily in younger age groups. To better understand the pathogenesis of these viruses in mammals, we used a mouse model to evaluate the relative virulence of selected 2009 H1N1 viruses and compared them to a representative human triple-reassortant swine influenza virus that has circulated in pigs in the United S...

In 2009, a novel swine-origin H1N1 influenza virus emerged in Mexico and quickly spread to other countries, including China. This 2009 pandemic H1N1 can cause human respiratory disease, but its pathogenesis remains poorly understood. Here, we studied the infection and pathogenesis of a new 2009 pandemic strain, A/Wenshan/01/2009 H1N1, in China in human airway epithelial cell lines compared with...

BACKGROUND A(H1N1)pdm09, a new influenza pandemic virus emerged in 2009. The A(H1N1)pdm09 infection had several unique characteristics which included rapid transmissibility and high morbidity in obese individuals, pregnant women and individuals suffering from chronic diseases. OBJECTIVES To study the relationships between A(H1N1)pdm09 influenza infection and infections with other respiratory ...

The objective of this study was to characterize H1N1 and H1N2 influenza A virus isolates detected during outbreaks of respiratory disease in pig herds in Ontario (Canada) in 2012. Six influenza viruses were included in analysis using full genome sequencing based on the 454 platform. In five H1N1 isolates, all eight segments were genetically related to 2009 pandemic virus (A(H1N1)pdm09). One H1N...

Since the emergence of the 2009 pandemic (H1N1) virus (2009/H1N1) in April 2009, cases of transmission from humans to pigs have been reported frequently. In our previous studies, four 2009/H1N1 variants were isolated from pigs. To better understand the phenotypic differences of the pig isolates compared with the human isolate, in this study mice were inoculated intranasally with different 2009/...

BACKGROUND Madagascar was one of the first African countries to be affected by the 2009 pandemic of influenza A virus subtype H1N1 [A(H1N1)pdm2009] infection. The outbreak started in the capital city, Antananarivo, and then spread throughout the country from October 2009 through February 2010. METHODS Specimens from patients presenting with influenza-like illness were collected and shipped to...

The global population has been exposed to the novel pandemic H1N1 influenza virus since mid March 2009, causing the expansion of respiratory illness around the world, including Thailand. To evaluate the antibody titers against human pandemic influenza (H1N1) in Thai people with influenza-like illness (ILI), 45 paired serum samples (acute and convalescent) were subjected to hemagglutination inhi...

munity influenza exposure, as measured according to the presence of ill household members. Frontline HCWs were defined as staff who worked in the emergency department , triage unit, or outpatient clinic and screened patients with suspected 2009 H1N1 influenza. In this hospital, all HCWs with suspected or confirmed 2009 H1N1 influenza have been required to report to the hospital's occupational h...

conclusions clinical signs and symptoms presented by patients infected with the influenza a h1n1 virus were similar to those described for seasonal influenza, although with more gastrointestinal disorders. results among the 232 enrolled cases, 126 patients (54.31%) were male and 106 patients (45.89%) were female. real time reverse rt-pcr test revealed that 18.1% of suspected children were posit...