Leprosy control depends solely on case detection and treatment with multi-drug therapy (MDT). – 3 This strategy is based on the principle that identifying and treating chronic infectious diseases with combinations of effective antibiotics limits the emergence and spread of new or existing antibiotic resistant pathogens. According to the World Health Organization (WHO), MDT formulated for lepros...

OBJECTIVES If leprosy is a public health problem, it is due to the disabilities it causes. Surprisingly little is known about the risk of disabilities. Even now, mainly cross-sectional studies report disability prevalence. The present study aims to report the risk of disability in pre and post-WHO multidrug therapy (MDT) in multibacillary leprosy patients and to assess the extent of the inciden...

BACKGROUND Multidisciplinary team (MDT) working is well established as the foundation for providing cancer services in the UK and elsewhere. A core activity is the weekly meeting (or case conference/tumor boards) where the treatment recommendations for individual patients are agreed. Evidence suggests that the quality of team working varies across cancer teams, and this may impact negatively on...

BACKGROUND Although the World Health Organization (WHO) has defined relapse in leprosy, it is often difficult to confirm a relapse, especially in paucibacillary (PB) patients. OBJECTIVE To study features of relapse cases in order to determine the information needed to allow better management of relapses in the leprosy control programme. DESIGN A retrospective survey by questionnaire was car...

OBJECTIVES This qualitative study examines how the Lung Cancer Nurse Specialist (LCNS) role operates and why they may be able to increase access to treatment. SETTING 4 Hospital NHS Foundation Trusts in England. DESIGN A multiple case study design using semistructured interviews, observation and Framework Analysis techniques. PARTICIPANTS Four LCNSs, comprised the 'cases'. Twenty four cli...

Pulmonary tuberculosis is a global problem requiring 6month MDT-DOTS continuous treatment. This time based treatment along with the combination of VCO nutritional supplement and/or Catfish-extracted albumin has shown a significant benefit on improving immune response, accelerating the conversion of BTA sputum, increasing nutritional states and improving chest X-ray imaging in people with active...

According to the Motor Theory of Speech Perception (MTSP), listeners perceive speech by way of the articulatory gestures they would perform themselves in producing a similar signal. The theory postulates a module that allows extracting gestural information from the signal. The gestures constitute the event perceived. According to the Modulation Theory (MDT), speech is modulated voice. Listeners...

Metazoans protect themselves from environmental toxins and virulent pathogens through detoxification and immune responses. We previously identified a small molecule xenobiotic toxin that extends survival of Caenorhabditis elegans infected with human bacterial pathogens by activating the conserved p38 MAP kinase PMK-1 host defense pathway. Here we investigate the cellular mechanisms that couple ...

Amplitude modulations in the speech convey important acoustic information for speech perception. Auditory steady state response (ASSR) is thought to be physiological correlate of amplitude modulation perception. Limited research is available exploring association between ASSR and modulation detection ability as well as speech perception. Correlation of modulation detection thresholds (MDT) and ...

Rationale: Hemophagocytic lymphohistiocytosis (HLH) secondary to methicillin-resistant Staphylococcus epidermidis (MRSE)related left-sided infectious endocarditis had never been reported before. In the last decade, daptomycin, a novel lipopeptide antibiotic, showed its excellent role in anti-Gram-positive bacteria, including soft tissue infection, bloodstream and deep tissueinfection. Patientco...