Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular dysplasia and severe, recurrent epistaxis is a common clinical phenotype associated with HHT. An intranasal treatment regime of diluted AvastinTM (Bevacizumab; recombinant humanized anti-vascular epithelial growth factor immunoglobin G1) using a pulsatile nasal irrigator has proven efficacious in clinical practice. Ho...

-Support Vector Machines (SVMs) map inputs vectors nonlinearly into a high dimensional feature space and construct the optimum separating hyperplane in space to realize signal classification. Automatic classification of digital modulation signals plays an important role in communication applications such as an intelligent demodulator, interference identification and monitoring, so many investig...

The authors present the case of a 41-year-old patient with hereditary hemorrhagic telangiectasia (HHT), who in the past had an aortic valve replacement surgery, currently takes anticoagulant drugs and has sustained an extensive trauma to the nose as a result of a dog bite. The HHT is diagnosed basing on the presence of at least three out of four symptoms or signs: spontaneous epistaxis, vascula...

BACKGROUND Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease that results in telangiectasia of the sinonasal tract, gastro-intestinal tract as well as possible arteriovenous malformations of the lung, liver and brain. One of the most common disease manifestations of HHT is epistaxis. Severe recurrent epistaxis necessitating iron therapy and blood transfusion is often ...

In this paper the use of the Hilbert-Huang Transform (HHT), for the decomposition and characterization of seismic ground response, is discussed. The HHT, integrated by the Empirical Mode Decomposition (EMD) and the Hilbert Transformation (HT), enables engineers to analyze non-stationary oscillation systems and to obtain more detailed intensity descriptions on time-varying frequency diagrams. Th...

OBJECTIVE The diagnosis of labor is currently one of the most difficult problems encountered by obstetrical healthcare providers. A major health problem is the increase in the rate of preterm delivery, which is responsible for 75% of all deaths in newborns. In addition, preterm delivery is associated with several cognitive and health problems in later life and enormous costs for the health syst...

STUDY OBJECTIVES To validate the feasibility of the Hilbert-Huang transform (HHT) based cardiopulmonary coupling (CPC) technique in respiratory events detection and estimation of the severity of apnea/hypopnea. METHODS The HHT-CPC sleep spectrogram technique was applied to a total of 69 single-lead ECG signals downloaded from the Physionet Sleep Apnea Database. Sleep spectrograms generated by...

BACKGROUND A variety of modalities are available for the control of recurrent epistaxis in hereditary hemorrhagic telangiectasia (HHT). Laser ablation, in particular potassium-titanyl-phosphate (KTP), has gained popularity as it coagulates the telangiectasia with minimal peripheral tissue injury. Septodermoplasty (SDP) also can be performed in the day surgery setting. Telangiectasia recurred, n...

Hereditary hemorrhagic telangiectasia (HHT) is caused by mutations in endoglin (ENG; HHT1) or ACVRL1/ALK1 (HHT2) genes and is an autosomal dominant vascular dysplasia. Clinically, HHT is characterized by epistaxis, telangiectases and arteriovenous malformations in some internal organs such as the lung, brain or liver. Endoglin and ALK1 proteins are specific endothelial receptors of the transfor...

Arteriovenous malformations (AVMs) are the major cause of haemorrhagic stroke in young adults, but the causal factors leading to AVM formation are unknown. An important clue is provided by the familial human disease Hereditary Haemorrhagic Telangiectasia (HHT), which is characterised by multi-organ AVMs and bleeding. HHT is inherited in an autosomal dominant manner and most patients carry mutat...