In tropical countries, malaria and hypertension are common diseases of pregnancy. They have physiopathologic similarities such as placental ischemia, endothelial dysfunction, and production of proinflammatory cytokines. Recent findings suggested their possible link. The authors conducted a case-control study to explore the relation between malaria and hypertension at Guediawaye, a hypoendemic m...

BACKGROUND Myocardial infarction (MI) is a cardiac cell death following the imbalance of supply and demand. Electrocardiography (ECG) is a diagnostic test for MI and can help the clinicians to estimate the severity and size of infarction, to suggest the artery related to the infarct and localize the pathology. The aim of this study is to evaluate the diagnostic value of ECG in posterior MI (PMI...

Anemia of CKD seems to be related to impaired production of renal erythropoietin (Epo). The glycosylation pattern of Epo depends on the synthesizing cell and thus, can indicate its origin. We hypothesized that synthesis of Epo from nonkidney cells increases to compensate for insufficient renal Epo production during CKD. We determined plasma Epo levels and Epo glycosylation patterns in 33 patien...

In this article, the general principles of genetically modified (GM) plant risk assessment and the regulatory framework for contained use and open field production of plant-made pharmaceuticals/plant-made industrials (PMP/PMI) are described. While significant progress has been made for the containment grown (plant cell culture) production of PMPs, with the first regulatory approval made by the ...

BACKGROUND Although malnutrition and sarcopenia are prevalent in cirrhosis, their impact on outcomes following liver transplantation is not well documented. METHODS The associations of nutritional status and sarcopenia with post-transplant infections, requirement for mechanical ventilation, intensive care (ICU) and hospital stay, and 1 year mortality were assessed in 232 consecutive transplan...

BACKGROUND Myocardial scars harbor areas of slow conduction and display abnormal electrograms. Pace-mapping at these sites can generate a 12-lead ECG morphological match to a targeted ventricular tachycardia (VT), and in some instances, multiple exit morphologies can result. At times, this can also result in the initiation of VT, termed pace-mapped induction (PMI). We hypothesized that in patie...

Metabolite in safety testing has been proposed for toxicity assessments. The question of how exposure of the synthetic metabolite compared with that of the formed metabolite was appraised kinetically by using physiologically based pharmacokinetic models, the (traditional) physiological model (TM), and segregated flow (SFM) models. The SFM differs from the TM and describes a partial (approximate...

BACKGROUND AND AIMS The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) gene is involved in mitochondrial tetrahydrofolate metabolism. Polymorphisms in MTHFD1L, including rs6922269, have been implicated in risk for coronary artery disease (CAD). We investigated the association between rs6922269 and known metabolic risk factors and survival in two independent cohorts ...

This paper briefly describes the existing PERMIS privilege management infrastructure (PMI), the new Integrated Project TrustCoM, and autonomic security. It then provides the business case for an autonomic PMI, and looks at the issues that will need to be resolved in order to make PERMIS more autonomic. In addition, it addresses the issues that TrustCoM will need to solve in order to maximise it...

In traditional multiple instance learning (MIL), both positive and negative bags are required to learn a prediction function. However, a high human cost is needed to know the label of each bag—positive or negative. Only positive bags contain our focus (positive instances) while negative bags consist of noise or background (negative instances). So we do not expect to spend too much to label the ...