O flurbiprofen (FB) apresenta efeitos colaterais comuns às drogas do tipo NSAIDs (Nonsteroidal anti-inflammatory drugs – drogas não esteróides anti-inflamatórias), devido à presença do grupo carboxílico livre. O objetivo desse estudo foi retardar esses efeitos adversos de origem gastrointestinal. Dez pró-fármacos derivados do FB foram sintetizados por amidação com ésteres etílicos de amino-ácid...

The effect of introducing a fifth large-scale space-time dimension to the equations of orbital dynamics was analysed in an earlier paper by the authors. The results showed good agreement with the observed flat rotation curves of galaxies. This analysis did not require the modification of Newtonian dynamics, but rather only their restatement in a five dimensional framework. The same analysis der...

Mass-dependent K isotopic fractionations can be used to trace cosmochemical, geological, and biological processes such as evaporation/condensation, core formation, magmatic processes, weathering, cellular metabolism. However, the application of stable isotopes has been limited by major isobaric interferences from Ar, common on conventional multi-collector inductively-coupled-plasma mass-spectro...

States and districts have embraced the goals of standards-based reform, but they have interpreted the rather broad objectives in their own unique ways. Merely setting the mark may not be enough to ensure adequate progress in our nation’s schools, Ms. Goertz warns. Comments Copyright Phi Delta Kappa International. Reprinted from Phi Delta Kappan, Volume 83, Issue 1, September 2001, pages 62-66. ...

1 Challenges in justifying the ICT expenditure The discussion commenced by discussing matters affecting the decisions to spend on ICT by government. Dr Kereteletswe indicated that we need to be in a position to justify to the Ministry of Finance and Development Planning the ICT expenditure. The chairman further added that currently the entire world is recovering from the economic melt-down henc...

Cloud computing is a significant alternative in today’s educational perspective. The technology gives the students and teachers the opportunity to quickly access various application platforms and resources through the web pages on-demand. Unfortunately, not all educational institutions often have an ability to take full advantages of the newest information technology. The paper analyzes possibi...

In this work, we present the Text Conditioned Auxiliary Classifier Generative Adversarial Network, (TAC-GAN) a text to image Generative Adversarial Network (GAN) for synthesizing images from their text descriptions. Former approaches have tried to condition the generative process on the textual data; but allying it to the usage of class information, known to diversify the generated samples and ...