هدف: با توجه به نگرانی‌های اجتماعی موجود در سال‌های اخیر دلیل بحران‌های اقتصادی، اجتماعی، مالی و زیست‌محیطی ناشی از تحریم‌ها، خط‌مشی دولت‌ها برای افزایش تاب‌آوری سمت اقتصاد مقاومتی سوق پیدا کرده است. هدف این پژوهش طراحی تبیین مدل سیاست‌گذاری دولت الکترونیک رویکرد وزارت علوم است.طراحی/ روش‌شناسی/ رویکرد: تحقیق حاضر لحاظ کاربردی توسعه‌ای بوده تکنیک تحلیل تم حاصل مصاحبه مدیران عالی اساتید دانشگاه ...

هدف: هدف پژوهش حاضر شناسایی و اولویت‌بندی تأثیرپذیری تأثیرگذاری ترجیحات کاری کارکنان نسل هزاره در سازمان‌های دولتی استان آذربایجان غربی بوده از نظر کاربردی است.طراحی/ روش‌شناسی/ رویکرد: این لحاظ نوع‌شناسی زمره پژوهش‌های آمیخته با رویکرد کیفی کمی پارادایم قیاسی-استقرایی است. بخش روش تحلیل محتوای دیمتل برای بررسی عوامل استفاده شده جامعه آماری اساتید مدیریتی بودند که توجه به پژوهش، نمونه‌گیری صورت...

The adoptive transfer of antigen-specific CD8+ T cells is a promising approach for the treatment of chronic viral and malignant diseases. In order to improve adoptive T cell therapy (ATT) of cancer, recent strategies aim at the antibody-based blockade of immunosuppressive signaling pathways in CD8+ T cells. Alternatively, adjuvant effects of immunostimulatory cytokines might be exploited to imp...

Presented here are femtosecond pump-probe studies on the water-solvated 7-azaindole dimer, a model DNA base pair. In particular, studies are presented that further elucidate the nature of the reactive and nonreactive dimers and also provide new insights establishing that the excited state double-proton transfer in the dimer occurs in a stepwise rather than a concerted manner. A major question a...

High performance liquid chromatography (HPLC) was used to follow the kinetics of the alkaline induced opening of the imidazole ring of 7-methyl-guanosine (7-meGuo). The kinetics show an initial rapid formation of a major transient intermediate and some minor products that were chromatographically separable into seven peaks. This phase of the reaction is followed by the formation of a dominant p...

IL-7 was previously shown to upregulate the expression of molecules important for interaction of CD4+ T cells with B cells. It is poorly studied whether IL-7 has a role in the biology of T follicular helper (Tfh) cells and whether IL-7 dysregulates the expression of B-cell costimulatory molecules on Tfh cells. We review the literature and provide arguments in favor of IL-7 being involved in the...

The basidiomycete Lentinula edodes (Le.) cytochrome P450, Le.CYP1 was functionally expressed in Saccharomyces cerevisiae. The microsomal fraction containing Le.CYP1 was prepared from the recombinant yeast and the Le.CYP1 was analyzed. The 7-ethoxycoumarin and benzo(a)pyrene were found to be the substrates of Le.CYP1 enzyme. Le.CYP1 converted 7-ethoxycoumarin to 7-hydroxycoumarin.

Methanomicrobium mobile requires a heat-stable factor present in ruminal fluid and in boiled cell extract from Methanobacterium thermoautotrophicum for growth. By comparing the growth of M. mobile with boiled cell extract with that observed with various methanogenic cofactors, we found that 7-mercaptoheptanoylthreonine phosphate (HS-HTP) supported sustained growth of M. mobile, at an optimal co...