BACKGROUND Bcl-2 protects cells from apoptosis and provides a survival advantage to cells over-expressing this oncogene. In addition, over expression of Bcl-2 renders cell resistant to radiation therapy. Recently, dichloroacetate (DCA) was proven to potentiate the apoptotic machinery by interacting with Bcl-2. In this study, we investigated whether treating human prostate cancer cells with DCA ...

Previously, we have demonstrated that deoxycholic acid (DCA)-induced signaling of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in primary hepatocytes is a protective response. In the present study, we examined the roles of the ERK and c-Jun NH(2)-terminal kinase (JNK) pathways, and downstream transcription factors, in the survival response of hepatocytes. DCA caused activation of the...

T HE EFFECT of desoxycorticosterone acetate (DCA) on potassium (K) metabolism has been investigated extensively in man, dog and rat; the characteristic response consists of kaluresis, hypokalemia and metabolic alkalosis. Dependence of these alterations in electrolyte metabolism on an adequate intake of sodium (Na) was recognized by Seldin, Welt and Cort (I). They reported that patients fed a lo...

Dynamic channel allocation (DCA) techniques have been discussed in detail in the excellent overview paper of Katzela and Naghshineh[1]. Zander [2] investigated the limitations of radio resource management in future wireless networks, while Peha et al [3] discussed the practical problems that may be encountered in designing a DCA based mobile radio system. In dynamic channel allocation all suffi...

Dichloroacetate (DCA) is a toxicant by-product from the chlorination disinfection process for municipal water. The levels would not affect people with normal renal and liver function. However, people with impaired renal or liver function may have an increased susceptibility to DCA toxicity as those are the organs affected by DCA. People (and rodents) with polycystic kidney disease (PKD) are pol...

Dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase (PDK), has been recently demonstrated as a promising nontoxic antineoplastic agent that promotes apoptosis of cancer cells. In the present study, we aimed to investigate the antitumor effect of DCA combined with 5-Fluorouracil (5-FU) on colorectal cancer (CRC) cells. Four human CRC cell lines were treated with DCA or 5-FU, or ...

A Distortion Contribution Analysis (DCA) obtains the distortion at the output of an analog electronic circuit as a sum of distortion contributions of its sub-circuits. Similar to a noise analysis, a DCA helps a designer to pinpoint the actual source of the distortion. Classically, the DCA uses the Volterra theory to model the circuit and its sub-circuits. This DCA has been proven useful for sma...