Two peptide bonds of staphylococcal enterotoxin C, were hydrolyzed concurrently at quite different rates during limited digestion with trypsin. A Lys-Val at about position 92 in the disulfide loop was the first bond cleaved, followed by a Lys-Asx at about position 57 on the NH2-terminal side of the loop. Preparations of singly cleaved material (enterotoxin C1-T1) contained about 93% of the clea...

A large deviation technique is used to calculate the microcanonical entropy function s(v,m) of the mean-field φ4-model as a function of the potential energy v and the magnetization m. As in the canonical ensemble, a continuous phase transition is found. An analytical expression is obtained for the critical energy vc(J) as a function of the coupling parameter J .

The articles [9], [1], [3], [4], [6], [5], [2], [7], and [8] provide the notation and terminology for this paper. We use the following convention: q, r, c, c1, c2, c3 are quaternion numbers and x1, x2, x3, x4, y1, y2, y3, y4 are elements of R. 0H is an element of H. 1H is an element of H. Next we state several propositions: (1) For all real numbers x, y, z, w holds 〈x, y, z, w〉H = x+y · i+ z · ...

The role of the classical complement pathway and specifically the first component, C1 in antibody-independent opsonization of type Ia group B Streptococcus (GBS) was investigated. For these studies a radiolabeled bacterial uptake assay was developed that was dependent on time and bacterial concentration and that required an intact classical complement pathway. To directly investigate the role o...

The biogenesis of cytochrome c1 involves a number of steps including: synthesis as a precursor with a bipartite signal sequence, transfer across the outer and inner mitochondrial membranes, removal of the first part of the presequence in the matrix, reexport to the outer surface of the inner membrane, covalent addition of heme, and removal of the remainder of the presequence. In this report we ...

AIMS The purpose of this study was to examine, in chronically treated heart failure patients vs control subjects, the influence of neurohumoral activation and aldosterone escape on arterial elastic behaviour, assessed by non-invasive mathematical lumped-parameter modelling of the compliance of the arterial system. METHODS AND RESULTS Radial arterial pulse waves were recorded non-invasively fo...

BACKGROUND Hereditary angioedema (HAE), caused by deficiency in C1-inhibitor (C1-INH), leads to unpredictable edema of subcutaneous tissues with potentially fatal complications. As surgery can be a trigger for edema episodes, current guidelines recommend preoperative prophylaxis with C1-INH or attenuated androgens in patients with HAE undergoing surgery. However, the risk of an HAE attack in pa...

BACKGROUND A number of studies have reported relationships of CYP2E1 RsaI/PstI polymorphisms with susceptibility to lung cancer in Chinese population. However, the epidemiologic results have been conflictive rather than conclusive. The purpose of this study was to address the associations of CYP2E1 RsaI/PstI polymorphisms with lung cancer risk in Chinese population comprehensively. MATERIALS ...

C1 inhibitor of serine proteases (C1-INH) performs a regulatory function in the complement system and vascular permeability. Deficiency C1-INH leads to various forms angioedema, including hereditary angioedema (HAE). The cause HAE is genetically determined violation synthesis C1-INH. A decrease level 50% relative norm an increase production bradykinin, which basis for diagnosis HAE. development...