Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease largely associated with cigarette smoke exposure (CSE) and characterized by pulmonary and extrapulmonary manifestations, including systemic inflammation. Liver growth factor (LGF) is an albumin-bilirubin complex with demonstrated antifibrotic, antioxidant, and antihypertensive actions even at extrahepatic sites. We aim...

The buffering effect of core self-evaluation (CSE) in stress research has received academic attention. However , most research in this area focused on its moderating effect on well-being. In the present study, we take a closer look at the moderating role of CSE in the relationship between challenge/hindrance stress and safety performance. Results indicated that challenge and hindrance stress we...

The development of software has become critical to progress in many important scientific and engineering fields. In general, the use of business/IT software engineering practices in these fields is relatively low. This paper describes the results of a survey of Computational Science & Engineering (CSE) developers that analyzed the current state of software engineering in the CSE community. Spec...

To compare measurements of left ventricular size and performance obtained by apical biplane cross-sectional echocardiography (CSE) and gated equilibrium radionuclide angiography (RNA), we studied 70 patients, all of whom had single-plane and 30 of whom had biplane left ventricular cineangiography. Wideangle, phased-array CSE images were obtained from two orthogonal apical views and left ventric...

Cigarette smoke contains high levels of reactive species. Moreover, cigarette smoke can induce cellular production of oxidants. The purpose of this study was to determine the effect of cigarette smoke extract (CSE)-derived oxidants on epithelial sodium channel (ENaC) activity in alveolar type 1 (T1) and type 2 (T2) cells and to measure corresponding rates of fluid clearance in mice receiving a ...

Human rhinovirus (HRV) infections induce epithelial cell production of chemokines that may contribute to the pathogenesis of exacerbations of chronic obstructive pulmonary disease (COPD) and asthma. Cigarette smoking is the predominant risk factor for the development of COPD and also aggravates asthma symptoms. We examined whether cigarette smoke extract (CSE) modulates viral inflammation by al...

Background and Objectives: Exhaled nitric oxide (NO) is decreased by smoking while oxides of nitrogen such as nitrites/nitrates (NOx) are increased. It was hypothesised that in vitro cigarette smoke extract (CSE) would either inhibit NO generation by increasing the NO synthase inhibitor, NG, NG-dimethyl-L-arginine (ADMA) or increase NOx levels via an oxidation pathway, which in turn could be in...

The confirmation of the cluster soft excess (CSE) by XMM-Newton has rekindled interest as to its origin. The recent detections of CSE emission at large cluster radii together with reports of O VII line emission associated with the CSE has led many authors to conjecture that the CSE is, in fact, a signature of the warm-hot intergalactic medium (WHIM). In this paper we test the scenario by compar...

RATIONALE Congenital diaphragmatic hernia (CDH) associated congenital anomalies are present in about 25%. Congenital short esophagus (CSE) is a relatively rare condition. Both CDH and congenital intrathoracic stomach caused by CSE can be diagnosed in utero. However, CSE can be easily misdiagnosed in utero. PATIENT CONCERNS We present a case of left CDH with CSE in a female neonate who was dia...

Accumulating evidence suggests a direct role for cigarette smoke in pulmonary vascular remodeling, which contributes to the development of pulmonary hypertension. However, the molecular mechanisms underlying this process remain poorly understood. Platelet-derived growth factor (PDGF) is a potential mitogen and chemoattractant implicated in several biological processes, including cell survival, ...