The primary function of mitochondria is energy production, a task of particular importance especially for cells with a high energy demand like cardiomyocytes. The B-cell lymphoma (BCL-2) family member BCL-2 adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) is linked to mitochondrial targeting after homodimerization, where it functions in inner membrane depolarization and permeabilization of t...

Three electromagnetic models are employed for the investigation of ultrawideband VHF scattering from tree trunks situated over flat and sloped terrain. Two of the models are numerical, each employing a frequency-domain integral-equation formulation solved via the method of moments (MoM). A body-of-revolution (BoR) MoM formulation is applied for a tree trunk on a flat terrain, implying that the ...

Wnt and Netrin signaling regulate diverse essential functions. Using a genetic approach combined with temporal gene expression analysis, we found a regulatory link between the Wnt receptor MOM-5/Frizzled and the UNC-6/Netrin receptor UNC-5. These two receptors play key roles in guiding cell and axon migrations, including the migration of the C. elegans Distal Tip Cells (DTCs). DTCs migrate post...

A higher order large-domain hybrid finite element – method of moments (FEM-MoM) technique is presented. The discretization and solving FEM and MoM parts of the problem and the coupling of the two methods is described. A benchmark example of analysis of a scatterer with pronounced curvature at resonant frequency is given, demonstrating accuracy and robustness of the presented hybrid technique.

The paper introduces a novel parallelizing compilation method for the MoM. The MoM (Map-oriented Machine) is an Xputer architecture featuring multiple data sequencers and “soft ALUs”. The compiler accepts C-source, which are restructured and partitioned into structural and sequential code providing parallelism at expression and statement level.

Over one-million patients worldwide have received metal-onmetal (MoM) hip replacements (hip resurfacing (HR) and total hip replacement (THR)).1 Good to excellent ten-year outcomes have been reported with certain HR devices by both designing and independent centres.2-4 However high short-term failure rates have been observed with other HR devices and stemmed MoM THRs.5-7 Adverse reaction to meta...

OBJECTIVES T-cells are considered to play an important role in the inflammatory response causing arthroplasty failure. The study objectives were to investigate the composition and distribution of CD4+ T-cell phenotypes in the peripheral blood (PB) and synovial fluid (SF) of patients undergoing revision surgery for failed metal-on-metal (MoM) and metal-on-polyethylene (MoP) hip arthroplasties, a...

OBJECTIVE The aim of this study was to investigate the association of the first trimester screening variables nuchal translucency (NT), pregnancy associated plasma protein (PAPP-A), and free beta-human chorionic gonadotrophin (βhCG) and birth weight, with a focus on the prediction of macrosomia. METHODS The database of our Fetal Medicine Unit was searched for all singleton pregnancies, who un...

BACKGROUND Metal-on-Metal (MoM) total hip arthroplasties (THA) are associated with pseudotumor formation and high revision rates. This prospective study analysed the clinical and wear analyses of 9 large Metal-on-Metal (MoM) total hip arthroplasties (THA) to understand the underlying mechanisms of failure. The MoM bearings were revised for multiple reasons; the main reason was pseudotumor forma...

In this paper, an electromagnetic analysis is presented for describing the influence of shielding in a rectangular waveguide. A hybridization based on the method of moments combined to the generalized equivalent circuit MoM-GEC is used to model the problem. This is validated by applying the MoM-GEC hybridization to investigate a diffraction structure. It consists of electromagnetic diffraction ...