In response to inflammation, pancreatic acinar cells can undergo acinar-to-ductal metaplasia (ADM), a reprogramming event that induces transdifferentiation to a ductlike phenotype and, in the context of additional oncogenic stimulation, contributes to development of pancreatic cancer. The signaling mechanisms underlying pancreatitis-inducing ADM are largely undefined. Our results provide eviden...

An interesting and real world problem is discussed in this paper in the kind of observer design of time-varying singular systems (Transistor Circuits). The results (approximate solutions) obtained using the Adomian Decomposition Method (ADM) and Singleterm Haar wavelet series (STHW) [12] methods are compared with the exact solutions of the time-varying singular systems. It is found that the sol...

The absorption of adriamycin (ADM) through the rat bladder epithelium was investigated histologically with a fluorescence microscope. ADM permeated through the epithelium into the lamina propria or the inner layer of the muscle within 15 min after instillation, but no further infiltration into the deeper part of the bladder wall was observed thereafter. In addition, fluorescence histological ev...

Abstract. When a spacetime takes Bondi radiating metric, and is vacuum and asymptotically flat at spatial infinity which ensures the positive mass theorem, we prove that the standard ADM energy-momentum is the past limit of the Bondi energy-momentum. We also derive a formula relating the ADM energy-momentum of any asymptotically flat spacelike hypersurface to the Bondi energy-momentum of any nu...

Multidrug resistance (MDR) represents a major challenge for successful chemotherapeutic treatment of cancer. Resveratrol (RES) is believed to have multiple bioactivities including anti-cancer, prevention of cardiovascular diseases, and anti-inflammatory. This study was aimed to examine the effect of resvertrol on human leukemic MDR K562/A02 cells. Treatment of combination of resveratrol and adr...

Abstract : In this article, a new method of analysis for linear and nonlinear stiff problems using the Adomian Decomposition Method (ADM) is presented. To illustrate the effectiveness of the ADM an example from linear and nonlinear stiff problems have been considered and compared with the single-term Haar Wavelet series (STHW)[9] and with exact solutions of the problems, and are found to be ver...

We thank Drs. Lim and Tan for their interesting comments (1) regarding our article (2). First, we agree that the adrenomedullin (ADM) is an intriguing candidate that may be involved in the pathogenesis of diabetes-related vascular dysfunction as suggested by Lim et al. (3) and others (4). In terms of the relationship between hyperfiltration and ADM, we are only aware of experimental data by Hir...

Myofibroblast differentiation induced by transforming growth factor-β (TGF-β) is characterized by the expression of smooth muscle α-actin (SMA) and extracellular matrix proteins. We and others have previously shown that these changes are regulated by protein kinase A (PKA). Adrenomedullin (ADM) is a vasodilator peptide that activates cAMP/PKA signaling through the calcitonin-receptor-like recep...

To understand the pathophysiological mechanisms of pulmonary arterial smooth muscle cell (PASMC) proliferation and extracellular-matrix accumulation in the development of pulmonary hypertension and remodeling, this study determined the effects of different doses of adrenomedullin (ADM) and adrenotensin (ADT) on PASMC proliferation and collagen synthesis. The objective was to investigate whether...

A comparative study is presented about the Adomian’s decomposition method (ADM), variational iteration method (VIM), and fractional variational iteration method (FVIM) in dealing with fractional partial differential equations (FPDEs).The study outlines the significant features of the ADM and FVIMmethods. It is found that FVIM is identical to ADM in certain scenarios. Numerical results from thre...