An electrospray ionization/mass spectrometry (ESI/MS)-based assay for the determination of acetylcholinesterase (AChE)-inhibiting activity in snake venom was developed. It allows the direct monitoring of the natural AChE substrate acetylcholine (AC) and the respective product choline. The assay scheme was employed in the screening for neurotoxic activity in fractions of the venom of Bothrops mo...

The aqueous extract of Verbascum mucronatum Lam. along with its fractions and secondary metabolites were assessed for their antioxidant, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitory activities. The antioxidant activity was evaluated by three methods: as 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, ferrous ion-chelating effect, and ferric-reducing...

Introduction: Surgery of inferior turbinates is a divisive subject. Surgical management includes functional and invasive procedures. There is currently no consensus on the most effective technique. Radiofrequency ablation is one of numerous interventions available for the treatment of nasal opstruction secondary to inferior turbinate hypertrophy. The goals of inferior turbinate surgery include ...

Leaves of Maytenus robusta (Celastraceae) were subjected to phytochemical investigation mainly directed at the isolation of pentacyclic triterpenes. The compounds friedelin (1), β-friedelinol (2), 3-oxo-21β-H-hop-22(29)-ene (7), 3,4-seco-friedelan-3,11β-olide (8), 3β-hydroxy-21β-H-hop-22(29)-ene (9), 3,4-seco-21β-H-hop-22(29)-en-3-oic acid (10), 3,4-seco-friedelan-...

In many countries, people are becoming more concerned about pesticide residues which are present in or on food and feed products. For this reason, several methods have been developed to monitor the pesticide residue levels in food samples. In this study, a bioactive paper-based sensor was developed for detection of acetylcholinesterase (AChE) inhibitors including organophosphate and carbamate p...

Alzheimer is an age-dependent disease mostly with genetic origin. In this disorder, acetylcholine is decreased which results in deterioration of short-term memory. Many researches have been focused on finding new sources of medications with more potency and less side effects and investigating acetylcholinesterase inhibitors (AChEIs) has been the center of many researches. In the present study, ...

5 LIST OF ORIGINAL PAPERS 6 ABBREVIATIONS 9 DESCRIPTION OF CONTRIBUTION 0 INTRODUCTION BACKGROUND 3 Historical Background 3 Anatomical Background 3 Health before surgery 5 Tonsillitis 5 Obstruction 5 Consequences 6 Well-being in the context of surgery 7 Preoperative Anxiety 7 Preoperative preparation 8 Anaesthesia 9 Surgical techniques for tonsil surgery 20 Tonsillectomy/TE 20 Tonsillotomy/TT 2...

The clinical evidence for the harmful effect of cortisone on patients infected with tubercle bacilli (American Trudeau Society, 1952; Fred et al., 1951; Traut and Ellman, 1952) has been supported by a series of laboratory studies on mice (Hart and Ress, 1950), rats (Cummings et al., 1952; Michael et al., 1950), guinea pigs (Spain and Molomut, 1950), and rabbits (Lurie et al., 1951). In the prec...

OBJECTIVES The determination of cholinesterase activity has been commonly applied in the biomonitoring of exposure to organophosphates and carbamates and in the diagnosis of poisoning with anticholinesterase compounds. One of the groups who are at risk of pesticide intoxication are the workers engaged in the production of these chemicals. AIMS The aim of this study was to assess the effect of...

Background: for advance grades of symptomatic hemorrhoids (grade III and IV) the author has innovated a procedure called radiofrequency ablation and fixation of hemorrhoids. The procedure is performed as a day care surgery. Patients and methods: the surgical technique and clinical follow-up of patients operated by this technique are presented. An Ellman dual frequency radiofrequency generator w...