Three mammalian bombesin receptor subtypes have been characterized: the gastrin-releasing peptide receptor (GRP-R), the neuromedin B receptor (NMB-R), and bombesin receptor subtype 3 (BRS-3). In a previous report we identified four amino acids that are critical for high affinity binding of bombesin and gastrin-releasing peptide (GRP) to the GRP-R. These four amino acids are conserved in all spe...

Previously, we have shown that bombesin-like peptide (BLP) promotes fetal lung development in rodents and humans but mediates postnatal lung injury in hyperoxic baboons. The present study analyzed the normal ontogeny of BLP and BLP receptors as well as the effects of BLP on cultured normal fetal baboon lungs. Transcripts encoding gastrin-releasing peptide (GRP), a pulmonary BLP, were detectable...

The cross-linking agent ethylene glycol-bis(succinimidyl succinate) was used to covalently link 125I-labeled gastrin releasing peptide (125I-GRP) to an Mr 75,000-85,000 surface protein in Swiss 3T3 cells that displays many characteristics of a specific receptor for peptides of the bombesin family. This protein was not present in other cell lines which do not exhibit receptors for bombesin-like ...

In this research, an electrically polarized graphene-polylactic acid (E-GRP) spacer is introduced for the first time by a novel fabrication method, which consists of 3D printing followed electrical polarization under high voltage electric field (1.5 kV/cm). The fabricated E-GRP was tested in osmotic-driven process (forward osmosis system) to evaluate its performance terms water flux, reverse so...

We have determined, by enzyme immunoassay, daily and circadian patterns of the concentrations of three peptides, which are located in the ventrolateral subdivision of the suprachiasmatic nucleus (SCN): vasoactive intestinal polypeptide (VIP), gastrin-releasing peptide (GRP), and neuropeptide Y (NPY). The contents of VIP and GRP, which are synthesized in the SCN, did not show circadian rhythms i...

an experiment was conducted to investigate the effects of using different levels of ginger rhizome powder (grp) and turmeric rhizome powder (trp) on production performance and some blood metabolites in laying hens. ninety 103-week old laying hens were divided into 5 treatments in a completely randomized design with 3 replicates and 6 birds in each cage. the birds were fed a corn-soybean meal ba...

9 http://ammtiac.alionscience.com http://wstiac.alionscience.com BACKGROUND Modern US Navy ships use considerable quantities of piping to carry fresh water, ballast water, chilled water, wastewater and fuels throughout the ship. Traditionally, copper-nickel (90Cu-10Ni) alloy pipes have been used, but they are heavy, subject to both corrosion and moderate bio-fouling, and are expensive to procur...

Gastrin-releasing peptide (GRP) and its receptor (GRPR) act as morphogens when expressed in colorectal cancer (CRC), promoting the assumption of a better differentiated phenotype by regulating cell motility in the context of remodeling and retarding tumor cell metastasis by enhancing cell-matrix attachment. Although we have shown that these processes are mediated by focal adhesion kinase (FAK),...

PURPOSE To determine whether antagonists of growth hormone-releasing hormone (GHRH) and bombesin/gastrin-releasing peptide (BN/GRP) can inhibit the orthotopic and metastatic growth of PC-3 human androgen-independent prostate cancers. EXPERIMENTAL DESIGN The effects of administration of GHRH antagonist MZ-J-7-118, BN/GRP antagonist RC-3940-II, and their combination on the growth and metastatic...