Three protocols were used to determine the effects of dietary selenium concentration on the development of gamma-glutamyl-transpeptidase (GGT)-positive foci and hepatocellular carcinoma induced by either diethylnitrosamine (DEN) or N-acetylaminofluorene in rats. In the first experiment, foci were induced by a carcinogenic dose of DEN (100 mg/kg body weight, p.o.) at 20-22 h after two-thirds par...

Oxazepam and related benzodiazepines are used in the treatment of anxiety. Carcinogenicity studies of oxazepam were performed with the F344 rat because of marked differences in tumor responses observed in NTP studies with B6C3F1 and Swiss-Webster mice compared to the results of Sprague-Dawley rat studies submitted to the FDA by a manufacturer to support registration of the drug. Groups of 50 ma...

In the current article, we provide in vitro efficacy evaluation of a unique accelerator-based neutron source, constructed at the Budker Institute of Nuclear Physics (Novosibirsk, Russian Federation), for boron neutron capture therapy (BNCT), which is particularly effective in the case of invasive cancers. U251MG, CHO-K1 and V79 cells were incubated and irradiated in various concentrations of bo...

PURPOSE To determine occupational exposure of the anesthesiologist and surgeon to nitrous oxide and desflurane during general anesthesia for ear-nose-throat (ENT) surgery in children and adults. METHODS An observational clinical trial was performed in ten children (C) and ten adults (A). Tracheas were intubated, in adults, with cuffed tubes and in children with uncuffed tubes. The operating r...

The aim of this study was to evaluate the dietary effect of mango extracts on lipid stability and the coloring of broiler chicken breast meat during frozen storage. The treatments consisted of broiler chicken diet without antioxidants (control) and diets containing antioxidants: 200 ppm of butylated hydroxytoluene (BHT), 200 ppm of mango peel extract (MPE), 400 ppm of MPE, 200 ppm of mango seed...

The interaction between plants and insects is dynamic, and may favour either the plant or the insect. Plant chemicals are deeply implicated in this relationship and influence insect behaviour. Here, we investigated the oviposition behaviour response of Culex quinquefasciatus mosquitoes based on the colour cues produced by Ipomoea cairica leaves extract. In this study, two sets of oviposition ch...

The effects of breathing CO continuously at high altitude on the mean electrical axis of the heart, hematocrit ratio and body weight were studied in laboratory rats. Laboratory rats were exposed for 6 weeks to: 100 or 500 ppm CO; 15,000 feet stimulated high altitude (SHA); or 100 or 500 ppm CO at SHA. SHA decreased body weight significantly; CO and CO-SHA interaction had no significant effect o...

An experimental study was carried over a period of 42 days using 160 day-old commercial broiler chicks (Ven Cobb) to study the effect of copper and flavomycin as feed additives on growth performance in broiler chicken. The birds were divided into four groups with four replicates of ten chicks in each replicate. The treatment (T1) was control with standard broiler ration and Cu as CuSO4 at 100 p...

Five organophosphates (OPs) (chlorpyrifos, chlorpyrifos methyl, fenthion, malathion, and temephos), 3 pyrethroids (bifenthrin, cypermethrin, and permethrin), 1 phenyl pyrazole (fipronil), 2 microbial pesticides (Bacillus thuringiensis serovar. israelensis [B.t.i.] and Bacillus sphaericus), and 3 insect growth regulators (IGRs) (diflubenzuron, methoprene, and pyriproxyfen) were evaluated against...

Inhaled nitric oxide (iNO) is commonly used in the treatment of very ill pre-term newborns. Previous studies showed that exogenous NO could affect endothelial NO synthase (eNOS) activity and expression in vascular endothelial cell cultures or adult rat models, but this has never been fully described in newborn rat lungs. We therefore aimed to assess the effects of iNO on eNOS expression and act...