IS1, the protein that is affected in the developmental disorder Lissen-cephaly, interacts with cytoplasmic dynein in several cell systems. As neuronal positioning is disrupted by this disease, LIS1 and dynein are assumed to be involved in neuronal migration. Now, live in vivo images from Tsai et al. (page 935) reveal that migration is just one facet of LIS1 function. Neuronal development was bl...

Library information science (LIS) should develop its foundation in terms of a philosophy of information (PI). This seems a rather harmless suggestion. Where else could information science look for its conceptual foundations if not in PI? However, accepting this proposal means moving away from one of the few solid alternatives currently available in the field, namely, providing LIS with a founda...

To examine the open access availability of Library and Information Science (LIS) research, a study was conducted using Google Scholar to search for articles from 20 top LIS journals. The study examined whether Google Scholar was able to find any links to full text, if open access versions of the articles were available and where these articles were being hosted. The results showed that the arch...

Introduction The principle of least effort (PLE), a concept advanced by the American linguist George Kingsley Zipf, indicates that people complete tasks by choosing the way of least effort among various options (Zipf, 1949). To prove that the PLE is an indication of human nature, Zipf analyzed numerous empirical data collected from various human activities and used mathematical formulae to expl...

INTRODUCTION Interstitial pulmonary fibrosis (IPF) is a frequent manifestation in patients with connective tissue disorders (CTD). Recently the ultrasound (US) criterion validity for its assessment has been proposed; however, the US scoring systems adopted include the study of several lung intercostal spaces (LIS), which could be time-consuming in daily clinical practice. The aim of this study ...

BACKGROUND Oral epithelial dysplasia (OED) and carcinoma in situ (CIS) are defined by dysplastic cells in the epithelium. Over a third of oral squamous cell carcinoma (OSCC) patients present with associated OED. However, accurate histopathological diagnosis of such lesions is difficult. Nucleus accumbens-associated protein 1 (NAC1) is a member of the Pox virus and Zinc finger/Bric-a-brac Tramtr...