BACKGROUND Diarrhea-predominant irritable bowel syndrome (IBS-d) significantly diminishes the health-related quality of life (HRQOL) of patients. Psychological and social impacts are common with many IBS-d patients reporting comorbid depression, anxiety, decreased intimacy, and lost working days. The Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire is a 34-item instrument develo...

BACKGROUND Irritable bowel syndrome (IBS) is a common functional bowel disorder. The post-infectious IBS (PI-IBS) occurs in IBS patients with a history of intestinal infection preceding the onset of symptoms. However, the underlying cause of PI-IBS is not fully understood, and the purpose of this study was to investigate the immune regulatory mechanism of PI-IBS. METHODS Participants enrolled...

Background The whole pathogenesis of diarrhea-predominant irritable bowel syndrome(IBS-D) is poorly understood. Our goal was to evaluate the expression change of microRNA-29a(miR-29a) in colonic epithelial cells in IBS rats and clarify the mechanism of miR-29a increasing the intestinal membrane permeability through aquaporins(AQPs). Methods The IBS-D rats models were induced by rectal distent...

TO THE EDITO R: Irritable bowel syndrome (IBS) is a common disorder characterized by persistent or recurrent abdominal pain and discomfort with altered bowel habits. It affects approximately 10%-20% of the adult population, with typical symptoms like abdominal pain, constipation, diarrhea and bloating. 1,2 Although IBS is not lethal, it can reduce quality of life and increase medical costs. Whi...

OBJECTIVE Few large-scale studies have examined the prevalence of irritable bowel syndrome (IBS) and the number of visits among IBS patients in a primary health care setting. The aim of this study was to assess the prevalence of IBS in primary health care in four Swedish counties. Another aim was to study the number of visits among the IBS patients. DESIGN A register-based study. Setting. A p...

BACKGROUND/AIMS The prevalence of irritable bowel syndrome (IBS) varies from 4% to 20% in different Asian nations. Prevalence of IBS in native North Indian community is not known. METHODS Between November 2008 to December 2009, we estimated the prevalence of IBS in a rural community of Ballabgarh block, located in Haryana state. A structured questionnaire based on Rome III module was used to ...

BACKGROUND The importance of interactions between the host and gut microbiota in the pathogenesis of irritable bowel syndrome (IBS) is becoming increasingly apparent. Probiotics offer a potential new treatment for IBS, but current results are conflicting, largely as a result of poorly designed trials and nonstandardisation of outcome measures. AIM To assess the efficacy of a liquid, multi-str...

Background/Aims Irritable bowel syndrome (IBS) patients commonly experience psychiatric disorders, such as depression and anxiety. This meta-analysis sought to compare depression and anxiety levels between IBS patients and healthy controls. Methods We searched major electronic databases (PubMed, EMBASE, MEDLINE, and Cochrane library) to find comparative studies on IBS patients and healthy con...

Abstract Introduction Irritable bowel syndrome (IBS) is the cause of numerous gastroenterological consultations. Due to multifactorial pathogenesis, treatment IBS difficult. Even management with new medications appears unsatisfactory. Recent reports on therapy highlight possible beneficial effect curcumin. The aim study was assess efficacy and safety curcumin in patients. Materials Methods Our ...

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by chronic abdominal symptoms in the absence of major mechanical, inflammatory, or biochemical diseases as determined by routine clinical examinations [1]. In the Rome III Diagnostic Criteria for Functional Gastrointestinal Disorders, IBS is defined by abdominal pain or discomfort associated with at least two...