INTRODUCTION The response to exogenous epinephrine (Ep) is difficult to predict given the multitude of factors involved such as broad pharmacokinetic and pharmacodynamic between-subject variabilities, which may be more pronounced in children. We investigated the pharmacokinetics and pharmacodynamics of Ep, co-administered with milrinone, in children who underwent open heart surgical repair for ...

BACKGROUND Adolescents born extremely preterm (EP; <28 weeks' gestation) and/or extremely low birthweight (ELBW; <1000 g) experience high rates of visual impairments, however the potential neural correlates of visual impairments in EP/ELBW adolescents require further investigation. This study aimed to: 1) compare optic radiation and primary visual cortical structure between EP/ELBW adolescents ...

The present studies report erythropoietin (Ep) production in primary cultures of a human renal carcinoma from a patient with erythrocytosis that has been serially transplanted to BALB/c nude mice. The levels of erythropoietin in the culture media were estimated using the exhypoxic polycythemic mouse assay (EHPCMA), fetal mouse liver erythroid colony-forming technique (FMLC), and a radioimmunoas...

The ability of a variety of affinity adsorbents to isolate erythropoietin (Ep) from contaminating proteins in crude preparetions of the hormone was examined. Of 3 lectin-agarose derivatives, 6 bound Ep but only 2, wheat germ agglutinin (WGA) and phytohemagglutinin (PHA), bound the hormone quantitatively. The extent to which PHA bound Ep depended on the isolectin composition of the PHA. The leuk...

The aim of this study was to compare how respiratory compensation point (RCP) and end-test power (EP) change in response to the same four-week high intensity interval training (HIIT). The power output associated with RCP and EP before and after HIIT were recorded in 24 recreationally active participants (14 men and 10 women). RCP was determined from an incremental exercise test and EP was deriv...

The endocochlear potential (EP) was reversibly decreased in adult gerbils by the intraperitoneal injection of furosemide, while cochlear functioning was monitored by measurement of distortion production otoacoustic emissions (DPE) at a range of stimulus intensities. Stimulus frequencies for DPEs were f1 = 6.8 and f2 = 8 kHz (f2/f1 = 1.18). Emissions monitored in the ear canal and scala media we...

In studi autoptici la prevalenza di embolia polmonare (EP) fatale o comunque concausa di morte varia fra il 3 e l’8%. Sempre dati autoptici, anche recenti, hanno dimostrato che oltre il 70% di EP maggiori non era stato diagnosticato in vita. Mentre la mortalità per EP non trattata è pari al 30%, il trattamento adeguato la riduce al 2-8%. Assume, pertanto, fondamentale importanza un corretto app...

Mast cells are implicated in the pathogenesis of a broad spectrum of immunological disorders. These cells release inflammatory mediators in response to a number of stimuli, including IgE-Ag complexes. The degranulation of mast cells is modified by PGs. To begin to delineate the pathway(s) used by PGs to regulate mast cell function, we examined bone marrow-derived mast cells (BMMC) cultured from...

We have recently shown that the prostaglandin E(2) (PGE(2)) receptor EP(3) plays an important role in suppression of colon cancer cell proliferation and that its deficiency enhances late stage colon carcinogenesis. Here we examined the effects of EP(3)-deficiency on two-stage skin carcinogenesis. 7,12-Dimethylbenz[a]anthracene (50 microg/200 microl of acetone) was thus applied to the back skin ...

(Ep) production was studied in control and nephrectomized sheep fetuses beginning at about 100 d of gestation. Fetuises were given injections of either 1.2 mg/d x 13 of L-T4, 12 mg, once every 5 d x 3 of DT or the vehicle alone. Fetal plasma samples for Ep determinations were obtained before and at intervals after the start of the treatment. Retictulocyte and hematocrit levels, and the percent ...