1. INTRODUCTION Past studies have shown that the use of coarse resolution SST products such as from the real-time global (RTG) SST analysis[1] or other coarse resolution once-a-day products do not properly portray the diurnal variability of fluxes of heat and moisture from the ocean that drive the formation of low level clouds and precipitation over the ocean. For example, the use of high resol...

Most neurons possess a single, nonmotile cilium that projects out from the cell surface. These microtubule-based organelles are important in brain development and neurogenesis; however, their function in mature neurons is unknown. Cilia express a complement of proteins distinct from other neuronal compartments, one of which is the somatostatin receptor subtype SST(3). We show here that SST(3) i...

The proposed sst(1) pharmacophore (J. Med. Chem. 2005, 48, 523-533) derived from the NMR structures of a family of mono- and dicyclic undecamers was used to design octa-, hepta-, and hexamers with high affinity and selectivity for the somatostatin sst(1) receptor. These compounds were tested for their in vitro binding properties to all five somatostatin (SRIF) receptors using receptor autoradio...

Pancreatic β-cells regulate glucose homeostasis by secreting insulin in response to glucose elevation and G protein-coupled receptor (GPCR) activation. Neuropeptide Y (NPY) and somatostatin (SST) attenuate insulin secretion through G(i) activation of Y(1) and SSTR(1&5) receptors, respectively. The downstream pathways altered by NPY and SST are poorly understood. Thus, we investigated these unde...

52 years of data (1949-2000) from the NCEP-NCAR reanalysis are used to investigate mechanisms involved in forcing and damping of Sea Surface Temperature (SST) variability in the South Atlantic Ocean. Organized patterns of coupled ocean-atmosphere variability are identified using EOF and SVD analyses. The leading mode of coupled variability consists of an SST pattern with a strong northeast-sout...

The dynamics of the Equatorial Atlantic zonal mode are studied using observed sea surface height (SSH), sea surface temperature (SST), and heat flux and reanalysis wind stress and upper ocean temperature. Principal oscillation pattern (POP) analysis shows that the zonal mode is an oscillatory normal-mode of the observed coupled system, obeying the delayed-action/recharge oscillator paradigm for...

The causes of the high pressure ridge at the North American west coast during winter 2013/14, the driest winter of the recent California drought, are examined. The ridge was part of an atmosphere–ocean state that included anomalies, defined relative to a 1979–2014 mean, of circulation across the Northern Hemisphere, warm sea surface temperatures (SSTs) in the tropical western and northeastern P...

Links between extreme wet conditions over East Africa and Indian Ocean sea surface temperatures (SST) are investigated during the core of the so-called short rain season in October–November. During periods of enhanced East African rainfall, Indian Ocean SST anomalies reminiscent of a tropical Indian Ocean dipole (IOD) event are observed. Ensemble simulations with an atmospheric general circulat...

A regional algorithm to estimate SST fields in the western North Pacific, where small oceanographic disturbance are often found, has been developed using Moderate Resolution Imaging Spectroradiometers (MODIS) aboard Terra and Aqua. Its associated algorithm, which includes cloud screening and SST estimation, is based on an algorithm for the Global Imager (GLI) aboard Advanced Earth Observing Sat...

Changes of the winter North Atlantic Oscillation (NAO) variability in response to different climate forcings, and their possible causes, are decomposed and investigated using a set of atmosphere-only timeslice experiments forced by sea surface temperature (SST) from coupled runs. The results indicate that the effects of uniform SST warming and direct CO2 radiative forcing could enhance NAO vari...