POAG: Primary Open Angle Glaucoma; IOP: Intra-Ocular Pressure; APP: Amyloid Precursor Protein, RGCs: Retinal Ganglion Cells; CSF: Cerebro-Spinal Fluid; APOE: Apolipoprotein E; AD: Alzheimer’s Disease; EGS: European Glaucoma Society; RNFL: Retinal Nerve Fiber Layer; GON: Glaucomatous Optic Neuropathy; PD: Parkinson’s Disease; NMDA: N-Methyl D-Aspartate; BDNF: Brain-Derived Neurotrophic Factor; E...

The University of Maryland Physics Education Research Group (UMd-PERG) carried out a five-year research project to rethink, observe, and reform introductory algebra-based (college) physics. This class is one of the Maryland Physics Department’s large service courses, serving primarily life-science majors. After consultation with biologists, we re-focused the class on helping the students learn ...

We generalize exactness to games with non-transferable utility (NTU). In an exact game for each coalition there is a core allocation on the boundary of its payoff set. Convex games with transferable utility are well-known to be exact. We study five generalizations of convexity in the NTU setting. We show that each of ordinal, coalition merge, individual merge and marginal convexity can be unifi...

PURPOSE To investigate whether postmenopausal hormone therapy (HT) increases retinal and ONH blood flow (BF) and protects ONH topography and the function of retinal ganglion cells in postmenopausal women (PMW). The effect of estradiol (E(2)) treatment on retinal tissue perfusion was also investigated in ovariectomized rats, an animal model for menopause. METHODS Sixty-four healthy PMW were re...

Increasing anatomical evidence indicates that large retinal ganglion cells (M-cells) are preferentially damaged in primary open angle glaucoma (OAG), while the smaller ganglion cells (P-cells) are relatively spared. In 13 patients with defined OAG and modest visual field defects, we evaluated the responses to stimuli that are expected to involve primarily the function of the P-pathway and compa...

The amplitude and phase of the second harmonic (15 Hz) of the electroretinographic responses to three different spatial frequency grating stimuli (0.25, 1 and 4 c/deg), reversed at 7.5 Hz, were studied i normal human subjects, before and 30 min after the systemic administration of three doses (0.071, 0.357 or 1.428 mg/kg) of a selective D2 blocker, l-sulpiride, to three populations of 18, 19, o...

OBJECTIVE To report the phenotype associated with the codon 172 RDS (gene for retinal degeneration slow) mutation in 11 separate families with an arginine-to-tryptophan substitution with common ancestry, and 1 family with an arginine-to-glutamine transition. PATIENTS Screening for RDS gene mutations was performed in 400 subjects with autosomal dominant retinal degeneration. Twelve families we...

BACKGROUND Osteo-odontokeratoprosthesis (OOKP) is an autologous transplantation procedure in which the cornea is replaced by an optical cylinder glued to a biological support. Patients undergoing OOKP surgery may develop a secondary glaucoma whose diagnosis, by means of standard diagnostic procedures, is often doubtful. METHODS In the present study pattern electroretinograms (PERGs), visual e...

PURPOSE To assess the effect of autosomal dominant optic atrophy (ADOA) on ON and OFF retinal ganglion cell (RGC) function by evaluating the ON and OFF components of the photopic negative response (PhNR). METHODS Twelve participants from six families with OPA1 ADOA and 16 age-matched controls were recruited. Electrophysiological assessment involved pattern ERGs (PERGs), focal (20°) and full-f...

PURPOSE To compare psychophysically determined spatial variations in photopic and scotopic sensitivity across the macula in patients with retinitis pigmentosa (RP) and normal visual acuity who manifest an abnormal high-density ring of fundus autofluorescence (AF). METHODS Eleven patients with a clinical diagnosis of RP were examined. All had rod-cone dystrophy (International Society for Clini...