OBJECTIVE Statins reduce cardiovascular risk and slow progression of coronary artery calcium (CAC). We investigated whether CAC progression and low-density lipoprotein (LDL) reduction have a complementary prognostic impact. METHODS AND RESULTS We measured the change in CAC in 495 asymptomatic subjects submitted to sequential electron-beam tomography (EBT) scanning. Statins were started after ...

The assessment of coronary artery calcium (CAC) by electron beam tomography (EBT) or multidetector spiral computed tomography (CT) and the evaluation of myocardial perfusion and function by use of myocardial perfusion single photon emission computed tomography (SPECT) (MPS) are both valuable in the noninvasive assessment of patients with suspected coronary artery disease (CAD). CAC provides uni...

Lymphoplasmacytic lymphomas are rare and may present with uncommon and devastating symptoms. We report a case of a 43-year-old male who presented with bleeding gums and sudden onset of bilateral blindness but was not on anticoagulants and had no family history of bleeding disorder. He had bilateral hyperpigmented infraorbital skin lesions, visual acuities (VA) of hand motion in both eyes (blind...

Ultraviolet radiation dosimetry has been performed with the use of a radiochromic film dosimeter called Gafchromic EBT for solar radiation exposure. The film changes from a clear colour to blue colour when exposed to ultraviolet radiation and results have shown that the colour change is reproducible within ±10% at 5 kJ m(-2) UV exposure under various conditions of solar radiation. Parameters te...

To describe the epicardial ventricular activation sequence in the intact human heart, we obtained epicardial maps from 11 patients with normal QRS undergoing open heart surgery. Epicardial breakthrough (EBT), defined as the emergence of a radially propagating epicardial wavefront, occurred in three to five sites in each patient, and was earliest in the anterior right ventricle, 7--25 msec (mean...

We studied the relationship of coronary artery calcification (CAC), a marker of coronary atherosclerosis, with prevalent clinical coronary artery disease (CAD) and established cardiovascular disease (CVD) risk factors in a type 1 diabetic population. At the 10-year follow-up examination of the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study cohort, 302 adults (mean age 38.1 +/- 7....

The concept of evidence-based toxicology (EBT) was proposed in 2006, but progress since that time has been impeded by differing definitions and goals. This paper describes the parallels and discontinuities between the approach and methods of evidence-based medicine and health care and those proposed for toxicology. The critical element of an evidence-based approach for either discipline is the ...