Objectives To evaluate the incidence, risk factors and clinical significance of four types tumor progression (TP) after microwave ablation (MWA) single hepatocellular carcinoma (HCC) <5 cm.Methods The data 340 treatment-naïve, HCC patients with a cm underwent MWA between April 2012 November 2017 were retrospectively reviewed. TPs including local (LTP), intrahepatic distant recurrence (IDR), agg...

The balance between endothelial nitric oxide (NO) and angiotensin II (Ang II) maintains the homeostasis of the cardiovascular and renal systems. We tested the hypothesis that increased oxidant stress linked to a functional imbalance between NO and Ang II might play a central pathogenetic role in salt-sensitive (SS) hypertension. We studied Dahl SS (DS) rats during the prehypertensive (5 days) a...

Endothelial dysfunction (ED) complicates hypertension and is a precursor of atherosclerosis. Reduced NO bioactivity, because of increased reduced NAD(P)H oxidase-derived reactive oxygen species (ROS), plays a critical role in ED. gp91phox, predominantly expressed in the endothelium and adventitia, is a subunit of NAD(P)H oxidase important for its activation in response to angiotensin (Ang) II. ...

Lysophosphatidylcholine (lysoPC) transferred from oxidatively modified low density lipoprotein (OxLDL) to the endothelial surface membrane has been shown to produce a selective unresponsiveness to cell surface receptor-regulated endothelium-dependent relaxation (EDR) in the rabbit aorta. To determine its mechanism we examined the effects of lysoPC on endothelial surface receptor-mediated transm...

Much of the early work in robotics focused on developing guaranteed plans for accomplishing tasks speciied at a high level. Such task speciications might be of the form \mesh these two gears", or \place part A inside region B". It is not always possible, however, especially in the realm of assembly planning, to generate guaranteed plans. For example, errors in tolerancing of the parts might ren...

Purpose To determine the effective dynamic range (EDR), retest reliability, and number of discriminable steps (DS) for mesopic and dark-adapted two-color fundus-controlled perimetry (FCP) using the S-MAIA (Scotopic-Macular Integrity Assessment) "micro-perimeter." Methods In this prospective cross-sectional study, each of the 52 eyes of 52 subjects with various macular diseases (mean age 62.0 ...

The age-related impairment of endothelium-dependent vasodilatation contributes to increased cardiovascular risk in the elderly. For primary and secondary prevention, aspirin can reduce the incidence of cardiovascular events in this patient population. The present work evaluated the effect of low-dose aspirin on age-related endothelial dysfunction in C57B/J6 aging mice and investigated its prote...

We studied the homogeneity, across clusters, of the color of the red sequence (the intercept of the color–magnitude relation) of 158 clusters and groups detected in the Early Data Release of the Sloan Digital Sky Survey (EDR–SDSS) in the redshift range 0.06 < z < 0.34. We found a high degree of homogeneity: the color of the red sequence shows an intrinsic scatter of 0.02 mag across clusters, su...

The emergence of extreme-drug-resistant (EDR) bacterial strains in hospital and nonhospital clinical settings is a big and growing public health threat. Understanding the antibiotic resistance mechanisms at the genomic levels can facilitate the development of next-generation agents. Here, comparative genomics has been employed to analyze the rapid evolution of an EDR Acinetobacter baumannii clo...

BACKGROUND Overexpression of matrix-metalloproteinases (MMPs) has been shown to lead to tissue damage in equine recurrent airway obstruction (RAO), as a misbalance with their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs), occurs. This favors irreversible pulmonary fibrosis formation. Increased levels of MMPs, TIMPs or altered ratios between them can be used as biomarke...