Elucidating the mechanisms that modulate calcium channels via opioid receptor activation is fundamental to our understanding of both pain perception and how opioids modulate pain. Neuronal voltage-gated N-type calcium channels (Cav2.2) are inhibited by activation of G protein-coupled opioid receptors (ORs). However, inhibition of R-type (Cav2.3) channels by μ- or κ-ORs is poorly defined and has...

Background: Diarrhoea complicates over half of admissions to hospital with severe acute malnutrition (SAM). World Health Organization (WHO) guidelines for the management of dehydration recommend the use of oral rehydration with ReSoMal (an oral rehydration solution (ORS) for SAM), which has lower sodium (45mmols/l) and higher potassium (40mmols/l) content than old WHO ORS. The composition of Re...

AIM This paper aims to identify factors that systematically predict why some countries that have tried to scale up oral rehydration solution (ORS) have succeeded, and others have not. METHODS We examined ORS coverage over time, across countries, and through case studies. We conducted expert interviews and literature and data searches to better understand the history of ORS scale-up efforts an...

263 INTRODUCTION Operationally Responsive Space (ORS) encompasses a vision of a new class of satellites that are rapidly developed and directly tasked by the warfighter in theater. The ORS Office, tasked with making this vision a reality, has developed a plan to rapidly develop and deploy space assets. However, the rapid development and evelopment of flight software for Operationally Responsive...

Low-Osmolarity Oral Rehydration Solution (L-ORS) and zinc supplementation remain the recommended gold standard for management of childhood diarrhoea. However, since 2005, there has been little or no progress in increasing use L-ORS children under 5 years with The study, therefore, assessed knowledge barriers to low osmolarity ORS among primary healthcare providers. study was a descriptive cross...

Topically applicable non-drug hair growth-promoting agents are of major medical and consumer interest. We have shown that stimulation the olfactory receptor (OR), OR2AT4, by odorant Sandalore®, prolongs human growth ex vivo, slows loss in telogen effluvium patients vivo. Here, we asked whether another OR, i.e. OR2A4/7, which promotes epidermal keratinocyte proliferation, unfolds similar propert...

In order to determine the optimum lithofacies for continental shale, reservoir characteristics of different types were studied based on a series experiments. The lacustrine organic-rich shale Shahezi Formation is divided into siliceous (ORS), argillaceous (ORA), calcareous (ORC), and mixed (ORM) shales. ORS, ORA, ORC, ORM shales all carried out comprehensive comparative analysis. results showed...

SummaryBackground Operating rooms (ORs) have strict requirements regarding cleanliness. While existing standards concerning the ventilation and staff guidelines are theoretically sufficient to subvert threats posed by micro-organisms within room, there exist potential sources of contamination due human activity around area. Studies exploring this influence on distribution micr...

Elucidating the mechanisms that modulate calcium channels via opioid receptor activation is fundamental to our understanding of both pain perception and how opioids modulate pain. Neuronal voltage-gated N-type calcium channels (Cav2.2) are inhibited by activation of G protein–coupled opioid receptors (ORs). However, inhibition of R-type (Cav2.3) channels by mor k-ORs is poorly defined and has n...

INTRODUCTION Programs aimed at reducing the burden of diarrhea among children under-five in low-resource settings typically allocate resources to training community-level health workers, but studies have suggested that provider knowledge does not necessarily translate into adequate practice. A diarrhea management program implemented in Bihar, Gujarat and Uttar Pradesh, India trained private sec...