Striatal dopamine (DA) transmission regulates motivation and action selection through the basal ganglia. Disruptions to DA signaling underlie a variety of common psychomotor disorders, including addiction disorders and Parkinson's disease. However, we require a better knowledge of the mechanisms that govern striatal DA transmission if we are to understand DA function and dysfunction fully. Acti...

Methamphetamine (MA) produces selective degeneration of dopamine (DA) neuron terminals without cell body loss. While excitatory amino acids (EAAs) contribute to MA toxicity, terminal loss is not characteristic of excitotoxic lesions nor is excitotoxicity selective for DA fibers; rather, EAAs may modulate MA-induced DA turnover, suggesting that DA-dependent events play a key role in MA neurotoxi...

Since the hypotensive and natrluretic role recently attributed to dopamine (DA) is difficult to test (free DA is usually undetectable in plasma) we measured free and conjugated DA by a newly developed method of hydrolysis of conjugated catecholamlnes in four pheochromocytoma, four primary aldosteronism and 34 essential hypertensive patients subjected to selective venous catheterization or perip...

Massive Open Online Courses (MOOCs) as a new shaking educational development provide the scene for achieving social inclusion and dissemination of knowledge. Anyhow, facilitating network learning experiences through creating an adaptive learning environment can pave the way for this open and energetic way to learning. The present study aimed to explore the possible role of Dynamic Assessment (D...

aim : the aim of this study was to search for metabolic biomarkers of crohn’s disease (cd). background : crohn's disease (cd) is a type of inflammatory bowel disease that causing a wide variety of symptoms. cd can influence any part of the gastrointestinal tract from mouth to anus. cd is not easily diagnosed because monitoring tools are currently insufficient. thus, the discovery of proper meth...

* Recebido (Received from) do Serviço de Anestesiologia (CET/SBA) da Faculdade de Medicina da Universidade Federal de Uberlândia (FM-UFU), Uberlândia, MG. 1. Professor Doutor da Disciplina de Anestesiologia e Responsável pelo CET/ SBA da FM-UFU. Membro da Comissão de Normas Técnicas Segurança em Anestesiologia/SBA. 2. Co-Responsável pelo CET/SBA da FM-UFU. 3. Anestesiologista do Serviço de Anes...

Correlations between substantia nigra (SN) dopamine (DA) cell activity and striatal extracellular DA were examined using simultaneous extracellular single-unit recordings and in vivo microdialysis performed in drug-naive rats and in rats treated repeatedly with haloperidol (HAL). Intact rats treated with HAL for 21-28 d exhibited significantly fewer active DA cells, indicating the presence of d...

To develop an in vitro model of methamphetamine (METH)-induced dopamine (DA) neurotoxicity, striatal synaptosomes were incubated at 37 degrees C with METH for different periods of time (10-80 min), washed once, then tested for DA transporter function at 37 degrees C. METH produced time- and dose-dependent reductions in the V(max) of DA uptake, without producing any change in K(m). Incubation of...

Hypoxic vasoconstriction (HV) is an intrinsic response of mammalian pulmonary and cyclostome aortic vascular smooth muscle. The present study examined the utilization of calcium during HV in dorsal aortas (DA) from sea lamprey and New Zealand hagfish. HV was temporally correlated with increased free cytosolic calcium (Ca2+c) in lamprey DA. Extracellular calcium (Ca2+o) did not contribute signif...