Aging is associated with learning deficits and a decrease in neuronal excitability, reflected by an enhanced post-burst afterhyperpolarization (AHP), in CA1 hippocampal pyramidal neurons. To identify the current(s) underlying the AHP altered in aging neurons, whole-cell voltage-clamp recording experiments were performed in hippocampal slices from young and aging rabbits. Similar to previous rep...

Metrifonate, a cholinesterase inhibitor, has been shown to enhance learning in aging rabbits and rats, and to alleviate the cognitive deficits observed in Alzheimer's disease patients. We have previously determined that bath application of metrifonate reduces the spike frequency adaptation and postburst afterhyperpolarization (AHP) in rabbit CA1 pyramidal neurons in vitro using sharp electrode ...

CA1 pyramidal neurons from animals that have acquired hippocampal tasks show increased neuronal excitability, as evidenced by a reduction in the postburst afterhyperpolarization (AHP). Studies of AHP plasticity require stable long-term recordings, which are affected by the intracellular solutions potassium methylsulphate (KMeth) or potassium gluconate (KGluc). Here we show immediate and gradual...

BACKGROUND Blended learning (BL) in a cell biology course of the premedical program at the Kasturba Medical College International Centre, Manipal, India, commenced in 2006. The program provides training in basic sciences to students, especially from the United States and Canada. The approach to the study was phenomenographic, with a qualitative study design using an open-ended questionnaire, fo...

The Internet of Things (IoT) is a technological topic with a very important societal impact. IoT application domains are various, such as smart cities, precision farming, smart factories, smart buildings, etc, and the diversity of these application domains is the source of the very high technological heterogeneity in the IoT, leading to interoperability issues. The semantic web principles and t...

Pyramidal neurons in the piriform cortex from olfactory-discrimination-trained rats have reduced postburst afterhyperpolarization (AHP), for 3 days after learning, and are thus more excitable during this period. Such AHP reduction is caused by decreased conductance of one or more of the calcium-dependent potassium currents, I(AHP) and sI(AHP), that mediate the medium and slow AHPs. In this stud...

This study aimed to develop a multi-stakeholder analysis identify the best strategies for integration of new Digital Energy Management Platform (DEMP). The municipality Loulé (South Portugal) was used as case study. A Strengths, Weaknesses, Opportunities, and Threats (SWOT) framework combined with an Analytical Hierarchy Process (AHP) TOWS Matrix employed analyse stakeholder’s perceptions propo...

The development of rural areas has an important role in supporting national development. Development is directed at the utilization available resources. Village Komba BUMDes one part process utilizing existing This study aims to: (1) Know management implementation system for Village, Luwu Regency; and (2) how to improve business Regency. used a qualitative descriptive approach, subject this res...