Drug delivery of combined cytotoxic and antivascular chemotherapies in multidrug nanoassemblies may represent an attractive way to improve the treatment of experimental cancers. Here we made the proof of concept of this approach on the experimental LS174-T human colon carcinoma xenograft nude mice model. Briefly, we have nanoprecipitated the anticancer compound gemcitabine conjugated with squal...

entrepreneurial passion has been shown to have important effect on starting and persistence of entrepreneurial behavior, however its causes has not yet been studied. this paper is aimed at investigating the effect of sq on three types of passion including passion for inventing, founding and developing with the mediating role of ideal entrepreneurial identity centrality. this descriptive survey ...

The serum concentrations of squamous cell carcinoma antigen (SCC-Ag) obtained from 124 surgically treated primary non-small cell lung cancer patients, including 75 adenocarcinomas (AD) and 49 squamous cell carcinomas (SQ), were studied. The changes in the SCC-Ag concentration, which were obtained before and one month after surgery, were analyzed. The 5-year survival rate of the patients with AD...

We hypothesized that foetal administration of SQ-29,548, a putative thromboxane receptor blocker, would prevent foeto-placental vasoconstriction produced by the thromboxane mimic U46619. Arterial blood gases, continuous monitoring of maternal and foetal heart rates and blood pressures were performed in chronically catheterized pregnant ewes. Foetal blood flows and vascular resistance were deter...

Planimetric studies were carried out on canine blood platelets fixed with formaldehyde. In the normal dog, the mean platelet area was 5.25 sq/i (SEM ± 0.34 sq/i). During the first 3 days following acute experimental thrombocytopenia, platelet area increased, averaging 9.5 sq/i (p < 0.01). The reactive thrombocytosis following splenectomy or nephrectomy was not accompanied by a rise in large pla...