There are undisclosed splices between lanes 2 and 3 for each panel in Fig 4A. Because no acute opioid effect on Akt phosphorylation was observed in naïve cells, the authors spliced out the Naloxone control band in order to save space. The authors have provided a corrected version of Fig 4, in which all splices are clearly demarcated with a vertical black line. The raw blots for each panel in Fi...

Pyridobenzimidazoles 6a-iwere synthesized in very good to excellent yields (81-96%) by the condensation of substituted N-phenyl-o-phenylenediamines 4a-d with indole/benzo[b]thiophene-3-aldehydes 5a-t inmethoxyethanol under reflux conditions. The diamines 4a-d were prepared byfirst treating 2-chloro-3-nitropyridine (1)with suitably substituted anilines 2a-d then reducing the resulting3-nitro-N-p...

New routes to the synthesis of various novel chiral maleimides are described. The oxabicyclic anhydride 2 readily available exo-Diels-Alder adduct of furan and maleic anhydride was used as a vehicle, which in turn reacted with hydrochlorides of amino acids 3a-f in the presence of Et3N with release of furan to give the requisite novel chiral imides 4a-f in good to moderate yields. The stereosele...

In the paper we consider some consequences of the Nonsymmetric Kaluza–Klein (Jordan–Thiry) Theory. We calculate primordial fluctuation spectrum functions, spectral indices, and first derivatives of spectral indices. In this paper we develop some ideas from Ref. [1]. We will refer to Ref. [1] in all the details of our considerations. Let us consider Eq. (3.313) from Ref. [1]. Φ(t) = (5 + 3a) √ 5...

A silver-free methodology was developed for the synthesis of unprecedented N-heterocyclic carbene ruthenium indenylidene complexes bearing a bidentate picolinate ligand. The highly stable (SIPr)(picolinate)RuCl(indenylidene) complex 4a (SIPr = 1,3-bis(2-6-diisopropylphenyl)imidazolidin-2-ylidene) demonstrated excellent latent behaviour in ring closing metathesis (RCM) reaction and could be acti...

In this paper, we give a decomposition of the moonshine module V ♮ with respect to an extremal Type II code over Z2k for an integer k ≥ 2. Then we obtain automorphisms of V ♮, some 4A and 2B elements of the Monster with respect to the decomposition. We give examples of such a decomposition for some k and give the McKay-Thompson series for a 4A element.

In the paper we consider some consequences of the Nonsymmetric Kaluza–Klein (Jordan–Thiry) Theory. We calculate primordial fluctuation spectrum functions, spectral indices, and first derivatives of spectral indices. In this paper we develop some ideas from Ref. [1]. We will refer to Ref. [1] in all the details of our considerations. Let us consider Eq. (3.313) from Ref. [1]. Φ(t) = (5 + 3a) √ 5...

Let k be a positive integer. In this paper, we study a parametric family of the sets of integers {k, Ak + 4A, (A+ 1)k + 4(A+ 1), d}. We prove that if d is a positive integer such that the product of any two distinct elements of that set increased by 4 is a perfect square, then d = (A4 + 2A3 +A2)k3 + (8A3 + 12A2 + 4A)k2 +(20A2 + 20A + 4)k + (16A+ 8) for 1 ≤ A ≤ 22 and A ≥ 51767.

Novel 11-substituted 3,11-dihydro-2H-benzo[6,7]thiochromeno[2,3-d][1,3]-thiazole-2,5,10-triones 4a-i were synthesized in 75-90% yields via the hetero-Diels-Alder reaction of 5-arylidene-4-thioxo-2-thiazolidinones with 1,4-naphthoquinone. The synthesized compounds were evaluated for their antineoplastic and antimycobacterial activities. A moderate selectivity against melanoma cancer cells (GI50 ...

The reaction of the 1,2-dihalodiborane(4) B2(NMe2)2Cl2 with the lithium tungsten salts Li[(η5C5H5)(R3P)(OC)2W] [R = Me (3a), Ph (3b)] yields via alkali salt elimination the phosphinesubstituted diborane(4)yl tungsten complexes [(η-C5H5)(R3P)(OC)2W-{B(NMe2)-B(NMe2)Cl}] [R = Me (4a), Ph (4b)]. Both compounds have been fully characterized in solution by NMR and IR spectroscopy and 4a additionally ...