To clarify the mechanisms by which Triton WR-1339 causes an elevation in the plasma fibrinogen level, we studied the time courses of hepatic mRNA expression for beta-chain fibrinogen, interleukin-6 (IL-6) and IL-6 receptor (R) by RT-PCR. After intravenous injection of Triton WR-1339 (150, 300 and 500 mg/kg) in Sprague-Dawley rats, the plasma level of fibrinogen and MCP-1 significantly and dose-...

Glucose-6-phosphatase activity in the rat brain in vivo was estimated by measuring the differential loss of tritium and carbon-14 from the glucose pool labeled by a mixture of [2-3H]glucose and [U-14C]glucose. The results provide no evidence of significant dephosphorylation of glucose-6-phosphate and do not support the hypothesis of a futile cycle involving glucose-6-phosphatase activity in the...

Lines of Action (LOA) is a two-person zero-sum game with perfect information; it is a chess-like game with a connection-based goal. In this note the 6 × 6 variant of LOA is weakly solved. A Proof-Number search method, PN, is used to compute that the game is a win for the first player (Black). Based on the results of solving the boards up to 6× 6, an optimistic time frame is given for solving 7×...