Sun-exposure leads to field cancerization where all keratinocytes harbor mutations and can potentially develop into a carcinoma. Here, we investigated the relationship of skin mutation load with keratinocyte cancer risk in case-control series. Finally, epidermal ablation was tested as an intervention reduce preventing cancers. Fifteen pairs patients high versus low burden were recruited matched...

The QCT (Quantitative Complexity Theory) algorithm has been applied to the analysis of folding process a protein composed 435 atoms, monitoring its complexity at each step thereof. simulated using Molecular Dynamics Simulation. revealed that, while in native state, protein’s configuration minimizes energy, reaches maximum.

Abstract Enantiomerically pure α-substituted β-hydroxyesters are important chiral building blocks for ligands, auxiliaries and β-lactam antibiotics. A two-step chemo-enzymatic procedure using lipase as biocatalyst is an efficient way to synthesize such products. To date, the methods described limited molecules that do not contain a center adjacent racemic carbinol, furthermore, they acylation. ...