نتایج جستجو برای: ژن فاکتور ix
تعداد نتایج: 47058 فیلتر نتایج به سال:
Carbonic anhydrase IX (CA IX) is an extracellular transmembrane homodimeric zinc metalloenzyme that has been validated as a prognostic marker and therapeutic target for several types of aggressive cancers. CA IX shares a close homology with other CA isoforms, making the design of CA IX isoform selective inhibitors challenging. In this paper, we describe the development of a new class of CA IX i...
بررسی اثر سیکل مکانیکی بر ریزنشت ترمیمهای Cl V کامپوزیت و گلاس آینومر و ارزیابی SEM آن دکتر اسماعیل یاسینی 1 - دکتر حمید کرمانشاه 2 - دکتر منصوره میرزایی2 - دکتر بهاران رنجبر امیدی 3 1- عضو مرکز تحقیقات دندانپزشکی و استاد گروه آموزشی دندانپزشکی ترمیمی و زیبایی دانشکده دندانپزشکی دانشگاه علوم پزشکی تهران 2- استادیار گروه آموزشی دندانپزشکی ترمیمی و زیبایی دانشکده دندانپزشکی دانشگاه ع...
Testicular germ cell tumors (TGCTs) represent a highly curable malignancy, however a small proportion of patients fails to be cured with cisplatin-based chemotherapy. Carbonic anhydrase IX (CA IX) is upregulated by hypoxia in several cancer types and correlates with a poor prognosis. The present translational study evaluated expression and prognostic value of CA IX in TGCTs. Surgical specimens ...
normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: to measure the amounts of fluoride released from fluoride-containing materials, four glass ionomer cements (fuji ix, fuji vii, fuji ix extra and fuji ii lc), a compomer (dyract extra) and a giomer (beautifil) were used in this study . methods: twenty cylindrical specimens were prepared from each material. the a...
The effect of acifluorfen-methyl on tetrapyrrole synthesis in greening chloroplasts of Cucumis sativus was examined. Formation of Mg-proto-porphyrin IX from delta-aminolevulinate was reduced 98% by 10 micromolar acifluorfen-methyl. Conversion of protoporphyrin IX to Mg-protoporphyrin IX was unaffected, but protoporphyrin IX synthesis from delta-aminolevulinate was blocked, indicating a site of ...
چکیده زمینه و هدف: امروزه بسیاری از پروتکلهای ژن درمانی با حامل های لنتی ویروسی انجام می شود. یکی از مهمترین فاکتورهایی که در تکوین پانکراس و رونویسی ژن انسولین نقش دارد فاکتور رونویسی Pancreatic & duodenal homeobox 1 (Pdx-1) است. هدف از این مطالعه بهینهسازی سازه لنتی ویروسی حاوی ژن pdx-1 برای ترانسفکشن سلولهای بنیادی در راستای ژن درمانی دیابت نوع 1 بود. روش بررسی: در این مطالعه تجربی...
Despite the fact that testicular germ cell tumors (TGCTs) are one of the most chemosensitive solid tumors, a small proportion of patients fail to be cured following cisplatin-based first line chemotherapy. Upregulation of carbonic anhydrase IX (CA IX) in various solid tumors is associated with poor outcome. The current prospective study investigated the prognostic value of serum CA IX level in ...
Alterations of the chemical structure of protoporphyrin IX markedly altered the activation of soluble guanylate cyclase purified from bovine lung. Hydrophobic side chains at positions 2 and 4 and vicinal propionic acid residues at positions 6 and 7 of the porphyrin ring (protoporphyrin IX, mesoporphyrin IX) were essential for maximal enzyme activation (K. = 7-8 nM; V, = 6-8 Kmol of cGMP/min/mg)...
background: bernard-soulier syndrome is a rare inherited bleeding disease caused by quantitative or qualitative defect of gpib/ix/v, a platelet complex that binds the von willebrand factor. the expression of gpib-ix-v complex can be evaluated by flow cytometry and confirmed by the absence of ristocetin-induced platelet aggregation in platelet-rich plasma. the main aim of the present study was t...
Intrinsic and acquired drug resistance of tumor cells still causes the failure of treatment regimens in advanced human cancers. It may be driven by intrinsic tumor cells features, or may also arise from micro environmental influences. Hypoxia is a microenvironment feature associated with the aggressiveness and metastasizing ability of human solid cancers. Hypoxic cancer cells overexpress Carbon...
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