Mice deficient for the mouse telomerase RNA (mTR-/-) and lacking telomerase activity can only be bred for approximately six generations due to decreased male and female fertility and to an increased embryonic lethality associated with a neural tube closure defect. Although late generation mTR-/- mice show defects in the hematopoietic system, they are viable to adulthood, only showing a decrease...

This paper presents a new approach to characterize subtle diffuse changes in multiple sclerosis (MS) using histograms derived from magnetization transfer ratio (MTR) images. Two major parts dominate our histogram analysis; 1) Classification of MTR histograms into control and MS subgroups; 2) Correlation with current disability, as measured by the EDSS scale (a measure of disease severity). Two ...

Folate deficiency has been implicated in the etiology of stomach cancer through abnormal DNA methylation and disrupted DNA synthesis and repair. Enzyme-coding genes involved in folate metabolism are often polymorphic. In a population-based study of 305 cases and 427 controls in Warsaw, Poland, we evaluated the risk of stomach cancer in relation to polymorphisms in folate-metabolizing genes, inc...

Serial monthly magnetization transfer (MT) imaging was performed to evaluate whether a change of the normal appearing white matter (NAWM), which precedes the appearance of enhancing lesions, is seen in patients with multiple sclerosis (MS). Every 4 weeks for 3 months, 10 patients with relapsing-remitting MS were scanned with a T1-weighted sequence, 20 minutes after injection with 0.3 mmol/kg ga...

Human tumors that lack telomerase maintain telomeres by alternative lengthening mechanisms. Tumors can also form in telomerase-deficient mice; however, the genetic mechanism responsible for tumor growth without telomerase is unknown. In yeast, several different recombination pathways maintain telomeres in the absence of telomerase-some result in telomere maintenance with minimal effects on telo...

Application of a simple approach for the soft-decision decoding of Maximum-Transition-Run (MTR) codes has been presented in this paper. A lowdemanded hardware realization have been proposed for soft-decision decoding in MTR basic AND, OR and XOR logic circuits. The suggested approach is explored over the two-track, two-head EPR4 partial response magnetic recording system. The overall two-track ...

Introduction Parkinson’s disease (PD) is characterized by degeneration of the dopaminergic (DAergic) neurons of the substantia nigra (1). Dopamine denervation induces an increase in corticostriatal glutamate transmission that is central to the pathophysiology of PD (2). The subthalamic nucleus also receives neuromodulatory inputs, notably DAergic axons from the substantia nigra. (3) For PD rese...

The scheduled maintenance cost of warships is the essential prerequisite and economic foundation to guarantee effective implementation maintenance, which directly influences quality efficiency operations. This paper proposes a multi-target regression algorithm based on multi-layer sparse structure (MTR-MLS) algorithm, achieve simultaneous prediction subentry costs warship total estimated by sum...

The work in this thesis applies magnetization transfer imaging (MTI) and conventional MRI measures (brain volume, T2 lesion load and enhancing lesions) to investigate the mechanisms underlying progression in primary progressive multiple sclerosis (PPMS), and identifies MR markers to predict and monitor progression. First, we demonstrated that MTI was sensitive to change in the normal appearing ...

Identification of remyelination is important in the evaluation of potential treatments of demyelinating diseases such as multiple sclerosis. Local injection of lysolecithin into the brain or spinal cord provides a murine model of demyelination with spontaneous remyelination. The aim of this study was to determine if quantitative, multicomponent T(2) (qT(2)) analysis and magnetization transfer r...