Advanced cutaneous squamous cell carcinoma (cSCC) can be managed with chemotherapy/radiotherapy, but often unsatisfactory clinical outcomes. Currently, no preclinical research has been performed to evaluate the efficacy of eribulin against cSCC. In this study, we investigate administration using cSCC lines and a novel patient-derived xenograft (PDX) model. (A431 DJM-1), was proven suppress tumo...

In this paper, we consider the existence of positive solutions to the following p Kirchhoff-type system ⎧⎪⎨⎪⎪⎩ −M (∫ Ω |∇u|pdx ) Δpu = g(x)|u|q−2u+ α α+β |u|α−2u|v|β , x ∈Ω, −M (∫ Ω |∇u|pdx ) Δpv = h(x)|v|q−2v+ β α+β |u|α |v|β−2v, x ∈Ω, u = v = 0, x ∈ ∂Ω, where Ω is a bounded domain in RN , M(s) = a + bsk , Δpu = div(|∇u|p−2∇u) is the p Laplacian operator, α > 1 , β > 1 , 1 < p < q < α +β < p∗ ...

Objective: The aim of this study was to investigate the effect of 12 weeks aerobic training on PDX-1 and GLUT2 gene expression in the pancreatic tissue of type 2 diabetic rats. Materials and Methods: 21 wistar male rats were placed in 3 groups (healthy, diabetic, aerobic diabetic). Diabetes was induced by peritoneum injection of nicotine amid. Training program lasted 12 weeks, five sessions pe...

We study the large time behavior of solutions of the PDE |vt |p−2vt = pv. A special property of this equation is that the Rayleigh quotient ∫ |Dv(x, t)|pdx/ ∫ |v(x, t)|pdx is nonincreasing in time along solutions. As t tends to infinity, this ratio converges to the optimal constant in Poincaré’s inequality. Moreover, appropriately scaled solutions converge to a function for which equality holds...

We adapt the inverse iteration method for symmetric matrices to some nonlinear PDE eigenvalue problems. In particular, for p ∈ (1,∞) and a given domain Ω ⊂ Rn, we analyze a scheme that allows us to approximate the smallest value the ratio ∫ Ω |Dψ| pdx/ ∫ Ω |ψ| pdx can assume for functions ψ that vanish on ∂Ω. The scheme in question also provides a natural way to approximate minimizing ψ. Our an...

Patient-derived xenograft (PDX) models have recently emerged as a highly desirable platform in oncology and are expected to substantially broaden the way in vivo studies are designed and executed and to reshape drug discovery programs. However, acquisition of patient-derived samples, and propagation, annotation and distribution of PDXs are complex processes that require a high degree of coordin...

We previously demonstrated that fetuses from undernourished pregnant rats exhibited increased beta-cell mass and hyperinsulinemia, whereas keeping food restriction until adult age caused reduced beta-cell mass, hypoinsulinemia, and decreased insulin secretion. Because these alterations can be related to insulin availability, we have now investigated early and long-term effects of protein calori...

Therapy for rhabdomyosarcoma (RMS) has generally been limited to combinations of conventional cytotoxic agents similar to regimens originally developed in the late 1960s. Recently, identification of molecular alterations through next-generation sequencing of individual tumor specimens has facilitated the use of more targeted therapeutic approaches for various malignancies. Such targeted therapi...