نتایج جستجو برای: ژن peroxiredoxin
تعداد نتایج: 17682 فیلتر نتایج به سال:
Despite considerable efficacy of arsenic trioxide (As2O3) in acute promyelocytic leukemia (APL) treatment, other non-APL leukemias, such as chronic myeloid leukemia (CML), are less sensitive to As2O3 treatment. However, the underlying mechanism is not well understood. Here we show that relative As2O3-resistant K562 cells have significantly lower ROS levels than As2O3-sensitive NB4 cells. We com...
Peroxiredoxin 1 (PRDX1) is a member of the peroxiredoxin family, which has been shown to act as an antioxidant, whose main function is to reduce reactive oxygen species in cells. The purpose of this article was to study the effect of PRDX1 overexpression on chondrocyte apoptosis in in vitro model (exposure to IL-1β) and explore its mechanism. PRDX1 overexpression was construed and infected chon...
OBJECTIVE The aim of this study was to investigate the role of peroxiredoxin 1 (Prdx1) in the invasiveness of pancreatic ductal adenocarcinoma (PDAC) cells. METHODS Immunohistochemistry was used to determine overexpression of Prdx1 in human PDAC tissues. Immunoprecipitation and immunocytochemistry were used to determine the interaction and intracellular distribution of Prdx1 and a member of t...
Ultraviolet B (UVB) irradiation generates reactive oxygen species (ROS), which can damage exposed skin cells. Mitochondria and NADPH oxidase are the two principal producers of ROS in UVB-irradiated keratinocytes. Peroxiredoxin V (PrxV) is a mitochondrial cytosolic cysteine-dependent peroxidase enzyme that robustly removes H2O2. We investigated PrxV’s role protecting epidermal keratinocytes agai...
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