نتایج جستجو برای: ژن pgc

تعداد نتایج: 19502  

2016
Haisong Jiang Sung-Ung Kang Shuran Zhang Senthilkumar Karuppagounder Jinchong Xu Yong-Kyu Lee Bong-Gu Kang Yunjong Lee Jianmin Zhang Olga Pletnikova Juan C Troncoso Shelia Pirooznia Shaida A Andrabi Valina L Dawson Ted M Dawson

Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder. Recent studies have implicated a role for peroxisome proliferator-activated receptor γ coactivator protein-1α (PGC-1α) in PD and in animal or cellular models of PD. The role of PGC-1α in the function and survival of substantia nigra pars compacta (SNpc) dopamine neurons is not clear. Here we find that there are four d...

2018
Liwen Zhang Jian Liu Fangfang Zhou Weiming Wang Nan Chen

The production of reactive oxygen species (ROS) is a common phenomenon in podocyte impairment, which leads to the irreversible progression of chronic kidney diseases, such as diabetic kidney disease (DKD). Previous research has indicated that peroxisome proliferator‑activated receptor γ (PPARγ) coactivator‑1α (PGC‑1α) participates in mitochondrial biogenesis and energy metabolism in certain mit...

Journal: :Circulation. Heart failure 2011
Joel Schilling Ling Lai Nandakumar Sambandam Courtney E Dey Teresa C Leone Daniel P Kelly

BACKGROUND Currently, there are no specific therapies available to treat cardiac dysfunction caused by sepsis and other chronic inflammatory conditions. Activation of toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) is an early event in Gram-negative bacterial sepsis, triggering a robust inflammatory response and changes in metabolism. Peroxisome proliferator-activated receptor-γ coactiv...

Journal: :Molecular and cellular biology 2014
Mario Baresic Silvia Salatino Barbara Kupr Erik van Nimwegen Christoph Handschin

Skeletal muscle tissue shows an extraordinary cellular plasticity, but the underlying molecular mechanisms are still poorly understood. Here, we use a combination of experimental and computational approaches to unravel the complex transcriptional network of muscle cell plasticity centered on the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a regulatory nexus in enduranc...

2003
James Rhee Yusuke Inoue J. Cliff Yoon Pere Puigserver Melina Fan Frank J. Gonzalez Bruce M. Spiegelman

The liver plays several critical roles in the metabolic adaptation to fasting. We have shown previously that the transcriptional coactivator peroxisome proliferator-activated receptor coactivator-1 (PGC-1 ) is induced in fasted or diabetic liver and activates the entire program of gluconeogenesis. PGC-1 interacts with several nuclear receptors known to bind gluconeogenic promoters including the...

Journal: :The Journal of biological chemistry 2005
Takayuki Akimoto Steven C Pohnert Ping Li Mei Zhang Curtis Gumbs Paul B Rosenberg R Sanders Williams Zhen Yan

Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) promotes mitochondrial biogenesis and slow fiber formation in skeletal muscle. We hypothesized that activation of the p38 mitogen-activated protein kinase (MAPK) pathway in response to increased muscle activity stimulated Pgc-1alpha gene transcription as part of the mechanisms for skeletal muscle adaptation. Here ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Lydia W S Finley Jaewon Lee Amanda Souza Valérie Desquiret-Dumas Kevin Bullock Glenn C Rowe Vincent Procaccio Clary B Clish Zoltan Arany Marcia C Haigis

Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation, and reactive oxygen species (ROS) scavenging in skeletal muscle and other tissues, and these processes are thought to be critical to the benefits of CR. PGC-1α is a transcriptional coactivator that regulates mitochondrial...

2008
Liangli WANG Yin LI Peng HU Christina T. TENG

ERR (oestrogen-related receptor)-α modulates the oestrogen signalling pathway and regulates genes participating in the physiological energy balance programme. Oestrogen and PGC-1α (peroxisome proliferator-activated receptor-γ coactivator-1α), the master regulator of the energy homoeostasis programme, both regulate the expression of ERRα through the MHRE (multihormone response element) of the ER...

2018
Shiraz Ahmad Haseeb Valli Samantha C Salvage Andrew A Grace Kamalan Jeevaratnam Christopher L-H Huang

Increasing evidence implicates chronic energetic dysfunction in human cardiac arrhythmias. Mitochondrial impairment through Pgc-1β knockout is known to produce a murine arrhythmic phenotype. However, the cumulative effect of this with advancing age and its electrocardiographic basis have not been previously studied. Young (12-16 weeks) and aged (>52 weeks), wild type (WT) (n = 5 and 8) and Pgc-...

2012
Anna Egger Marijana Samardzija Vithiyanjali Sothilingam Naoyuki Tanimoto Christina Lange Silvia Salatino Lei Fang Marina Garcia-Garrido Susanne Beck Michal J. Okoniewski Albert Neutzner Mathias W. Seeliger Christian Grimm Christoph Handschin

The peroxisome proliferator-activated receptor c coactivator 1 (PGC-1) proteins are key regulators of cellular bioenergetics and are accordingly expressed in tissues with a high energetic demand. For example, PGC-1a and PGC-1b control organ function of brown adipose tissue, heart, brain, liver and skeletal muscle. Surprisingly, despite their prominent role in the control of mitochondrial biogen...

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