نتایج جستجو برای: ژن tcdb
تعداد نتایج: 16071 فیلتر نتایج به سال:
Motivation: The growing number of specialized databases in molecular biology, coupled with the huge increase in the availability of molecular data, necessitates the development of automatic methods for finding and adding relevant information to these databases. Results: We show how a general protein database (Swiss-Prot) can be used as a source of data for a more specialized one (TCDB, the Tran...
A 28-year-old man presented with abdominal pain and diarrhea (10-12 Bristol type 7 stools per day; Bristol scale range, 1-7 [1, separate hard pieces; 7, watery stool])1 after completing a course of azithromycin for pneumonia. He was diagnosed with Clostridium difficile infection (CDI) with a positive stool polymerase chain reaction (PCR) for the toxin B (tcdB) gene. Laboratory studies showed un...
During 11-12 August 2014, a Protein Bioinformatics and Community Resources Retreat was held at the Wellcome Trust Genome Campus in Hinxton, UK. This meeting brought together the principal investigators of several specialized protein resources (such as CAZy, TCDB and MEROPS) as well as those from protein databases from the large Bioinformatics centres (including UniProt and RefSeq). The retreat ...
Fruits and vegetables are rich in flavonoids, and ample epidemiological data show that diets rich in fruits and vegetables confer protection against cardiovascular, neurodegenerative and inflammatory diseases, and cancer. However, flavonoid bioavailability is reportedly very low in mammals and the molecular mechanisms of their action are still poorly known. This review focuses on membrane trans...
Clostridium difficile infections (CDI) have emerged as a major cause of healthcare associated disease, and recent epidemiological evidence also suggests an important role in community-acquired diarrhea. This increase is associated with specific types, especially PCR ribotypes 027 and 078, which are sometimes referred to as "hypervirulent". Over the past years major advances have been made in ou...
Clostridium difficile toxins A and B are members of an important class of virulence factors known as large clostridial toxins (LCTs). Toxin action involves four major steps: receptor-mediated endocytosis, translocation of a catalytic glucosyltransferase domain across the membrane, release of the enzymatic moiety by autoproteolytic processing, and a glucosyltransferase-dependent inactivation of ...
Controlled regulation of the switchable behavior of the supramolecular network is central to the potential application in the molecular scale nanodevices. In this work, it is reported that the reversible accommodation of the guest molecules in the nanoporous supramolecular network can be regulated by the UV/visible light. The nanoporous complex template of TCDB/4NN-Macrocycle(trans,trans,trans,...
Abstract The nosocomial pathogen Clostridioides difficile colonizes the gastrointestinal tract of patients following microbiome disruption and secretes two major virulence factors toxin A (TcdA) B (TcdB). Approximately 25% infected with C. experience recurrent infection, rate recurrence increases each subsequent infection. quality protective capacity adaptive immune response generated infection...
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