The general availability of pure 02 in cylinders gave medicine a powerful therapeutic tool. Until 1952 oxygen was used freely in high concentrations in many premature baby units, in the knowledge that many babies were hypoxic and on the assumption that it would in any case do no harm. The demonstration that high concentrations of inspired 02 could lead to retrolental fibroplasia in premature ba...

The present paper include some aspects and facets of geometry. Mathematics Subject Classification: 00-02, 01-02.

BACKGROUND Reduction of brain volume (brain atrophy) during healthy brain aging is well documented and dependent on genetic, lifestyle and environmental factors. Here we investigated the possible dependence of brain gray matter volume reduction in the absence of the Human Leukocyte Antigen (HLA) allele DRB1*13:02 which prevents brain atrophy in Gulf War Illness (James et al., 2017). METHODS S...

Cytochrome c oxidase (EC 1.9.3.1) is the site of 02 utilization in the inner mitochondrial membrane of all higher organisms. It contains two haems (a and a3) and two copper atoms. Reduced haem a3 is able to bind 02 and catalyse its reduction to water. Flash photolysis of CO-inhibited cytochrome oxidase in the presence of 02 at low temperatures (-95 to -1250C) leads to the formation of oxycytoch...

The relation between defects of Abelian gauges and instantons is discussed for explicit examples in the Laplacian Abelian gauge. The defect coming from an instanton is pointlike and becomes a monopole loop with twist upon perturbation. The interplay between magnetic charge, twist and instanton number – encoded as a Hopf invariant – is investigated with the help of a new method, an auxiliary Abe...

Hypersensitivity reactions are the most frequent dose-limiting adverse reactions to Escherichia coli-derived asparaginase in pediatric acute lymphoblastic leukemia (ALL) patients. The aim of the present study was to identify associations between sequence-based Human Leukocyte Antigen Class II region alleles and asparaginase hypersensitivity in a Hungarian ALL population. Four-digit typing of HL...

Background: Identification of antigen-specific T cells has yielded valuable information on pathologic process and the disease state. Assays for quantification of inflammatory cytokines or lytic-granule molecules have been generally used to evaluate antigen specific T cell response, however their applicability have been hampered due to the limited source of autologous antigen-presenting target c...