Extended-spectrum -lactamases (ESBLs), such as the plasmid-mediated class A TEMand SHV-type enzymes, have developed by stepwise mutations in their structural genes, resulting in either single or multiple amino acid changes in the encoded enzymes, and these changes sufficiently remodel the active site to allow attack on aminothiazolyl compounds. Since they were first identified at the beginning ...

Linear programming has many important practical applications, and has also given rise to a wide body of theory. See Section 49.9 for recommended sources. Here we consider the linear programming problem in the form of maximizing a linear function of d variables subject to n linear inequalities. We focus on the relationship of the problem to computational geometry, i.e., we consider the problem i...