نتایج جستجو برای: 0027
تعداد نتایج: 405 فیلتر نتایج به سال:
Celiac disease (CD) is an immune mediated disorder in which mucosal autoantibodies to the enzyme transglutaminase 2 (TG2)1 are generated in response to the exogenous antigen gluten2 in individuals who are HLA-DQ2 or HLA-DQ83. We assessed in a comprehensive and non-biased manner the IgA anti-TG2 response by expression cloning of the antibody repertoire on ex vivo isolated intestinal antibody-sec...
The intestinal expression pattern and general tissue distribution of the M. 40 kD putative epithelial autoantigen in ulcerative colitis were re-examined by in situ two and three colour immunofluorescence staining including the murine monoclonal antibody 7E,2H,2. The intestinal distribution was also compared with the epithelial codeposition of IgGI and activated complement (C3b and terminal comp...
Background: In some European countries and the US it is mandatory to assess and treat pain. In Pubmed there are more than 240 papers when searching for “skin conductance” and “pain”. Aims: The aim is to review the utility of the skin conductance responses (SCR)/sec to assess pain in infants and children. Study design: Two searches in Pubmed, where one includes the key words “skin conductance”, ...
Interactions between transcription and signaling are fundamentally important for understanding both the structure and function of genetic pathways and their role in diseases such as cancer. The finding that β-catenin/TCF4 and JNK/c-Jun cooperate has important implications in carcinogenesis. Previously, we found that binding of c-Jun and β-catenin/TCF4 to the c-jun promoter is dependent upon JNK...
Background: Patients (pts) with psoriatic arthritis (PsA) and axial involvment exhibit greater disease activity quality of life impairments compared those without involvment. Objectives: To characterize PsA pts involvement compare efficacy UPA vs placebo (PBO) in involvement. Methods: In SELECT-PsA 1 ( NCT03104400 ; N=1705, non-biologic DMARD IR) 2 NCT03104374 N=642, biologic IR), active (≥3 sw...
آزمایش حاضر به منظور بررسی اثر گیاه سیاه¬دانه بر عملکرد، سیستم ایمنی و جمعیت میکروبی دستگاه گوارش بلدرچین¬های ژاپنی تحت آفلاتوکسیکوزیس انجام گردید. به این منظور تعداد 600 قطعه جوجه بلدرچین ژاپنی 7 روزه در یک آزمایش فاکتوریل در قالب طرح کاملاً تصادفی با 8 تیمار شامل: 1) تیمار بدون آفلاتوکسین-بدون سیاه¬دانه، 2) تیمار حاوی نیم درصد سیاه¬دانه-بدون afb1، 3) تیمار حاوی یک درصد سیاه¬دانه-بدون afb1، 4) ...
مجموعه انتهای چشم کوچک شاتون، بوش برنزی، باس پیستون و گژن پین از جمله قطعات حساس درون موتور هستند که در شرایط کاری سخت و دمای بالا قرار دارد. در تحقیق حاضر به مطالعه جامع تحلیل تنش، خستگی و هیدرودینامیک روغن کاری و سطوح تماسی در مجموعه انتهای کوچک شاتون، باس پیستون، گژن پین و بوش برنزی موتور ملی ef7 پرداخته شد. برای هر تحلیل بیش از سه روش ارائه شد، آزمون تجربی کرنش سنجی و آزمون دوام جهت صحه گذا...
We demonstrate how a specification for the standard evaluation of a simple functional programming language can be systematically extended to a specification for mixed evaluation. Using techniques inspired by natural semantics we specify a standard evaluator by a set of inference rules. The evaluation of programs is then performed by a restricted kind of theorem proving in this logic. We then de...
BACKGROUND Xerostomia is the most common late side-effect of radiotherapy to the head and neck. Compared with conventional radiotherapy, intensity-modulated radiotherapy (IMRT) can reduce irradiation of the parotid glands. We assessed the hypothesis that parotid-sparing IMRT reduces the incidence of severe xerostomia. METHODS We undertook a randomised controlled trial between Jan 21, 2003, an...
Computational steering remains an impressive yet challenging opportunity for computational scientists. In this paper, we examine our practical experiences when we used computational steering on four existing scienti c applications. In particular, this paper enumerates the concrete steps required for speci c computational steering on each individual application. We then provide an evaluation of ...
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