PURPOSE Newly designed antiepileptic drugs (AEDs) are being evaluated for their efficacy in preventing seizures and for their toxic profiles. We investigated and compared the toxic effects of two dibenz[b,f]azepine derivatives with anticonvulsant activity, 10,11-dihydro-10-hydroxyimino-5H-dibenz[b,f]azepine-5-carboxamide (BIA2-024) and (S)-(-)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f] azepine-5-c...

The impact of untreated and partially treated domestic wastewater on rivers and community water sources continues to raise health and safety concerns. The organisms of concern in domestic wastewater include enteric bacteria, viruses, and protozoan cysts. Table 1 summarizes the most common microorganisms found in domestic wastewater and the types of human diseases associated with them. Based on ...

Introduction The patients characterized with chronic subclinical inflammation even during attack-free periods, are now considered to have an increased risk of atherosclerotic complications as well as other autoinflammatory disease. Damage to the arterial wall due to atherosclerosis causes increased arterial stiffness. Pulse wave velocity (PWV), a noninvasive measure of arterial stiffness, is ac...

OBJECTIVES Our objectives were to assess clinical signs and diagnoses associated with primary HIV-1 infection among infants. METHODS We analyzed data from a clinical trial (HIV Prevention Trials Network Protocol 024) in sub-Saharan Africa. Study visits were conducted at birth, at 4-6 weeks, and at 3, 6, 9, and 12 months. The study population comprised live born, singleton, first-born infants ...

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A dipeptidy} cftrbexypeptidase (DCP) activity was detected in cell-free extracts of Pseudomonas sp. W024. After purification and characterization the enzyme was found to be homogeneous by SDS-PAGE, and had a molecu)ar mass of 74,eOODa by SDS-PAGE and 72,OOODa by gel filtration, i dicating that it is monomeric. The isoeleenic point was 5.2 and optimum pH was 6.5-7.0. It showed a specific activit...