The anticancer agents 4'-demethylepipodophyllotoxin-4-(4,6-O-ethylidene-beta-D-glucopyra noside (etoposide) (VP16-213) and 4'-demethylepipodophyllotoxin-4-(4,6-O-thenylidene-beta-D-gl ucopyranoside (teniposide) (VM26) produce cytotoxicity by inhibiting type II topoisomerase, resulting in an accumulation of DNA breaks. By using alkaline elution techniques to assess in vivo DNA break frequencies,...

Phytochemical screening and antimicrobial activity of chloroform, acetone and methanolic extracts of Calotropis procera (Ait.) R. Br. (Asclepiadaceae) flowers were tested against various pathogens such as Salmonella paratyphi, S. paratyphi A, Bacillus subtilis, Bacillus thuringiensis, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli. Phytoc...

Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility...

Department of Chemistry, Avinashilingam Deemed University for Women, Coimbatore641 043 ABSTRACT Lipophilicity which plays an important role in research into the structure-activity relationship of drug action has been theoretically predicted for few chromen-2-ones and chromen-2-thiones using commercial software HyperChem 7.0 and an internet computational software ALOGPS 2.1. In the compounds ana...

The use of indwelling medical devices--pacemakers, prosthetic joints, catheters--is rapidly growing and is often complicated by infections with biofilm-forming microbes that are resistant to antimicrobial agents and host defense mechanisms. We investigated for the first time the use of microbe-specific monoclonal antibodies (MAbs) as delivery vehicles for targeting biofilms with cytocidal radia...