We investigated actin's function in vesicle recycling and exocytosis at lamprey synapses, and show that FM1-43 puncta and phalloidin-labeled filamentous actin (F-actin) structures are colocalized, yet recycling vesicles are not contained within F-actin clusters. Additionally, phalloidin also labels a plasma membrane-associated cortical actin. Injection of fluorescent G-actin revealed activity-i...

29 Entry into mitosis triggers profound changes in cell shape and cytoskeletal 30 organisation. Here, by studying microtubule remodelling in human flat mitotic cells, 31 we identify a two-step process of interphase microtubule disassembly. First, a 32 microtubule stabilizing protein, Ensconsin, is inactivated in prophase as a 33 consequence of its phosphorylation downstream of Cdk1/CyclinB. Thi...

31 Climate models are essential tools for assessing future climate change. In making predictions, it 32 is beneficial to examine simulations from various models that are developed at centers around the 33 world. The simple average over an ensemble of such models is often taken as the optimal 34 prediction, which in studies of current climate is demonstrated as being more accurate than 35 relyin...

In the title compound, C39H36N2O4S, the piperidine ring adopts a twisted half-chair conformation. In the pyrrolo-thia-zole fused-ring system, the pyrrole ring adopts an envelope conformation (with the C atom bound to the thia-zole ring being the flap atom) and the thia-zole ring also exhibits an envelope conformation (with the N atom bound to the pyrrole ring as the flap). The mol-ecular struct...