The urea tests of renal efficiency commonly mentioned in the literature include (a) simple estimation of blood urea concentration, (b) determination of urine urea concentration following ingestion of urea, and (c) observations on the relationship between blood and urine urea concentrations. From a comparative study of these three methods, the general conclusion reached in this hospital (1) was ...

In normal rats, vasopressin and hyperosmolality enhance urea permeability (P(urea)) in the terminal, but not in the initial inner medullary collecting duct (IMCD), a process thought to occur through the UT-A1 urea transporter. In the terminal IMCD, UT-A1 is detected as 97- and 117-kDa glycoproteins. However, in the initial IMCD, only the 97-kDa form is detected. During streptozotocin-induced di...

SUMO activating enzyme 1 (SUMO E1) is the first enzyme in sumoylation pathway and an important cancer drug target. However, only a few inhibitors were reported up to now that includes three natural products, semi-synthetic protein inhibitors and one AMP mimic. Here, we report the identification of quinazolinyloxy biaryl urea as a new class of SUMO E1 inhibitors. The most active compound of this...

UNLABELLED BACKGROUND This study was done to obtain concentrated polyunsaturated fatty acid (PUFA) linoleic acid (LA; 18:2) and monounsaturated fatty acid (MUFA) oleic acid (OA; 18:1) from Jatropha curcas seed oil by urea complexation. Urea complexation is a method used by researchers to separate fatty acids (FAs) based on their molecular structure. Effects the ratio of urea-to-FAs, crystall...

The Lake Magadi tilapia (Alcolapia grahami) is an unusual fish, excreting all its nitrogenous waste as urea because of its highly alkaline and buffered aquatic habitat. Here, using both physiological and molecular studies, we describe the mechanism of branchial urea excretion in this species. In vivo, repeated short-interval sampling revealed that urea excretion is continuous. The computed urea...

Cefpodoxime Proxetil (Poorly water soluble drug), when prepared as solid dispersion showed improved solubility and dissolution. So the main purpose of this investigation was to increase the solubility and dissolution rate of Cefpodoxime Proxetil by the preparation of its solid dispersion with urea using solvent evaporation method. Physical mixtures and solid dispersions of Cefpodoxime Proxetil ...

Evidence is presented that the enzymes catalyzing the three reactions involved in urea cleavage in Candida utilis, biotin carboxylation, urea carboxylation, and allophanate hydrolysis occur as a complex of enzymes. The allophanate-hydrolyzing activity could not be separated from the urea-cleaving activity using common methods of protein purification. Further, urea cleavage and allophanate hydro...

HOUPT, T. RICHARD, AND KATHERINE A. HOUPT. Transfer of urea nitro,gen across the rumen wall. Am. J. Physiol. 2 1 /t(6) : 1296-1303. 1968.-Net movement of urea N across the wall of Pavlov-type rumen pouches was measured in three goats and one sheep as urea concentration difference between pouch and blood was varied. When urease activity of the rumen epitheliurn was depressed by vigorous rinsing ...

Urea is important for the conservation of body water due to its role in the production of concentrated urine in the renal inner medulla. Physiologic data demonstrate that urea is transported by facilitated and by active urea transporter proteins. The facilitated urea transporter (UT-A) in the terminal inner medullary collecting duct (IMCD) permits very high rates of transepithelial urea transpo...