We point out that the contentions of Chapline (astro-ph/0503200)[1] that (i) General Relativity (GR) is in conflict with Quantum Mechanics (QM) and (ii) GR fails even on macroscopic length scales are incorrect and based on (i) misunderstanding of GR and (ii) completely misconceived “thought experiments”. Even without introduction of any QM, GR actually does not allow formation of any Event Hori...

Glucocorticoids (GC) regulate cell fate and immune function. We identified the metastasis-promoting methyltransferase, metastasis-related methyltransferase 1 (WBSCR22/Merm1) as a novel glucocorticoid receptor (GR) regulator relevant to human disease. Merm1 binds the GR co-activator GRIP1 but not GR. Loss of Merm1 impaired both GR transactivation and transrepression by reducing GR recruitment to...

The activity of the Ca2+/calmodulin-dependent protein kinase IV/Gr (CaMKIV/Gr) is shown to be strictly regulated by phosphorylation of three residues both in vitro and in response to antigen receptor-mediated signaling in lymphocytes. One residue, Thr-200, is indispensable for enhancement of Ca2+/calmodulin-dependent basal activity by CaMKIV/Gr kinase. This event requires Ca2+/calmodulin in the...

Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular mechanisms mediating these effects are poorly understood. Here we identify the glucocorticoid receptor (GR) target gene, serum- and glucocorticoid-inducible kinase 1 (SGK1), as one such mechanism. Using a human hippocampal progenitor cell line, we found that a small molecule inhibitor for SGK1, GSK650394, co...

The activity of the Ca/calmodulin-dependent protein kinase IV/Gr (CaMKIV/Gr) is shown to be strictly regulated by phosphorylation of three residues both in vitro and in response to antigen receptor-mediated signaling in lymphocytes. One residue, Thr-200, is indispensable for enhancement of Ca/calmodulin-dependent basal activity by CaMKIV/Gr kinase. This event requires Ca/calmodulin in the full-...

Through the use of photobleaching techniques, we examined the dynamic interaction of three members of the transcription apparatus with a target promoter in living cells. The glucocorticoid receptor (GR) interacting protein 1 (GRIP-1) exhibits a half maximal time for fluorescent recovery (tau(R)) of 5 s, reflecting the same rapid exchange as observed for GR. In contrast, the large subunit (RPB1)...

The Galois ring GR$(4^\Delta)$ is the residue $Z_4[x]/(h(x))$, where $h(x)$ a basic primitive polynomial of degree $\Delta$ over $Z_4$. For any odd larger than $1$, we construct partition GR$(4^\Delta) \backslash \{0\}$ into $6$-subsets type $\{a,b,-a-b,-a,-b,a+b\}$ and $3$-subsets $\{c,-c,2c\}$ such that invariant under multiplication by nonzero element Teichmuller set in and, if not multiple ...

BACKGROUND AND AIM Current treatment of gingival recession (GR) is limited to surgical procedures. We describe a case series of 18 patients with GR who were treated with a botanical patch and rinse following standard conservative therapy. CASE SERIES DESCRIPTION: A total of 22 sites with GR > 1 mm were studied. Following scaling and root planing (SRP) and oral hygiene instruction, patients rece...

Let v(G) and γ(G) denote the number of vertices and the domination number of a graph G, respectively, and let ρ(G) = γ(G)/v(G). In 1996 B. Reed conjectured that if G is a cubic graph, then γ(G) ≤ dv(G)/3e. In 2005 A. Kostochka and B. Stodolsky disproved this conjecture for cubic graphs of connectivity one and maintained that the conjecture may still be true for cubic 2-connected graphs. Their m...

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates most biological responses to 2,3, 7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related aromatic hydrocarbons. Although the role of the AHR in control of drug metabolism and endocrine disruption is partly understood, we know little about the regulation of the AHR itself by endocrine factors. Our work with ...