نتایج جستجو برای: 1 insulin
تعداد نتایج: 2870504 فیلتر نتایج به سال:
Insulin degrading enzyme (IDE) exists primarily as a dimer being unique among the zinc metalloproteases in that it exhibits allosteric kinetics with small synthetic peptide substrates. In addition the IDE reaction rate is increased by small peptides that bind to a distal site within the substrate binding site. We have generated mixed dimers of IDE in which one or both subunits contain mutations...
INTRODUCTION: Leptin is a hormone resulting from the obesity gene which could be important in the pathogenesis of the insulin. Only limited data concerning the interaction of insulin, glucose tolerance and free leptin are available and no data exist on the potential influence of free vs. bound circulating leptin. We, therefore, studied percentage of free to total leptin in diabetic patients. ...
Information regarding metabolic profile in different physiological periods of ewes can assist veterinarians to monitor the herd health and productive performance. Furthermore, the relationships among the metabolic parameters can be used to detect the effect of each parameter on another one. Five clinically healthy adult Ghezel ewes were selected at 4 weeks before parturition and evaluated at 4 ...
Background: Recently, there has been growing efforts to elucidate the molecular mechanism of amyloid formation and investigating effective compounds for inhibiting of amyloid structures. Investigation of the fibrillation process through its induction and inhibition using specific compounds such as aromatic derivatives provide useful information for stabilizing the protein structure. In the pres...
Background & aimsThe physiological regulation and contribution of the multiple phosphorylation sites insulin receptor substrate 1 (IRS1) to pathogenesis resistance is unknown. Our aims were map phosphorylated motifs IRS1 in skeletal muscle from people with normal glucose tolerance (NGT; n = 11) or type 2 diabetes mellitus (T2DM; 11).MethodsSkeletal biopsies obtained under fasted conditions duri...
Background and Objective: Acceptable control of blood glucose is one of the most important goals of treatment management in diabetic children. An insulin therapy regimen with multiple daily injection or continuous subcutaneous insulin infusion has been admitted as a desirable therapeutic approach in children with diabetes mellitus type 1. This study was designed to evaluate the effect of intens...
Type 1 diabetes mellitus patients on intensive insulin therapy use advanced carbohydrate counting to proper dose prandial insulin. Therefore, the patient’s ability accurately estimate meal’s content is paramount. However, despite its significance, several studies show that estimates far from ideal and identify need for continuous education counting. In this context, authors have proposed in pre...
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